Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases.

Sara Courtneidge, R. M. Kypta, J. A. Cooper, A. Kazlauskas

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We previously demonstrated that src family tyrosine kinases associate with activated platelet-derived growth factor receptors. We have now investigated the requirement for tyrosine phosphorylation sites in the human platelet-derived growth factor receptor for this binding. Tyrosine 857, but not tyrosine 751, is required for efficient association. Furthermore, even though src family tyrosine kinases associate with receptors lacking tyrosine 751, they are not activated, implying that association does not invariably lead to activation.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalCell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Volume2
Issue number10
Publication statusPublished - Oct 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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