Abstract
Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 132-135 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 155 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 11 1993 |
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Keywords
- Basal ganglia
- Glutamate release
- Membrane current
- Platelet-activating factor
- Presynaptic inhibition
- Synaptic transmission
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Platelet-activating factor inhibits excitatory transmission in rat neostriatum. / Jiang, Zhi-Gen; Yue, Tian Li; Feuerstein, Giora.
In: Neuroscience Letters, Vol. 155, No. 2, 11.06.1993, p. 132-135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Platelet-activating factor inhibits excitatory transmission in rat neostriatum
AU - Jiang, Zhi-Gen
AU - Yue, Tian Li
AU - Feuerstein, Giora
PY - 1993/6/11
Y1 - 1993/6/11
N2 - Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.
AB - Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.
KW - Basal ganglia
KW - Glutamate release
KW - Membrane current
KW - Platelet-activating factor
KW - Presynaptic inhibition
KW - Synaptic transmission
UR - http://www.scopus.com/inward/record.url?scp=0027280872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027280872&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90690-M
DO - 10.1016/0304-3940(93)90690-M
M3 - Article
C2 - 8104322
AN - SCOPUS:0027280872
VL - 155
SP - 132
EP - 135
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -