Platelet-activating factor inhibits excitatory transmission in rat neostriatum

Zhi Gen Jiang; Tian Li Yue; Giora Feuerstein

doi:10.1016/0304-3940(93)90690-M

Platelet-activating factor inhibits excitatory transmission in rat neostriatum

Zhi Gen Jiang, Tian Li Yue, Giora Feuerstein

Otolaryngology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.

Original language	English (US)
Pages (from-to)	132-135
Number of pages	4
Journal	Neuroscience Letters
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90690-M
State	Published - Jun 11 1993

Keywords

Basal ganglia
Glutamate release
Membrane current
Platelet-activating factor
Presynaptic inhibition
Synaptic transmission

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(93)90690-M

Cite this

@article{5861922caa224a3b9947c92f03a95258,

title = "Platelet-activating factor inhibits excitatory transmission in rat neostriatum",

abstract = "Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.",

keywords = "Basal ganglia, Glutamate release, Membrane current, Platelet-activating factor, Presynaptic inhibition, Synaptic transmission",

author = "Jiang, {Zhi Gen} and Yue, {Tian Li} and Giora Feuerstein",

year = "1993",

month = jun,

day = "11",

doi = "10.1016/0304-3940(93)90690-M",

language = "English (US)",

volume = "155",

pages = "132--135",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Platelet-activating factor inhibits excitatory transmission in rat neostriatum

AU - Jiang, Zhi Gen

AU - Yue, Tian Li

AU - Feuerstein, Giora

PY - 1993/6/11

Y1 - 1993/6/11

N2 - Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.

AB - Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.

KW - Basal ganglia

KW - Glutamate release

KW - Membrane current

KW - Platelet-activating factor

KW - Presynaptic inhibition

KW - Synaptic transmission

UR - http://www.scopus.com/inward/record.url?scp=0027280872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027280872&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90690-M

DO - 10.1016/0304-3940(93)90690-M

M3 - Article

C2 - 8104322

AN - SCOPUS:0027280872

VL - 155

SP - 132

EP - 135

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

Platelet-activating factor inhibits excitatory transmission in rat neostriatum

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this