Platelet-activating factor inhibits excitatory transmission in rat neostriatum

Zhi Gen Jiang, Tian Li Yue, Giora Feuerstein

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalNeuroscience Letters
Volume155
Issue number2
DOIs
StatePublished - Jun 11 1993

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Keywords

  • Basal ganglia
  • Glutamate release
  • Membrane current
  • Platelet-activating factor
  • Presynaptic inhibition
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)

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