Platelet-activating factor inhibits excitatory transmission in rat neostriatum

Zhi Gen Jiang; Tian Li Yue; Giora Feuerstein

doi:10.1016/0304-3940(93)90690-M

Platelet-activating factor inhibits excitatory transmission in rat neostriatum

Zhi Gen Jiang, Tian Li Yue, Giora Feuerstein

Otolaryngology

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16 Scopus citations

Abstract

Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.

Original language	English (US)
Pages (from-to)	132-135
Number of pages	4
Journal	Neuroscience Letters
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90690-M
State	Published - Jun 11 1993

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Keywords

Basal ganglia
Glutamate release
Membrane current
Platelet-activating factor
Presynaptic inhibition
Synaptic transmission

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Jiang, Z. G., Yue, T. L., & Feuerstein, G. (1993). Platelet-activating factor inhibits excitatory transmission in rat neostriatum. Neuroscience Letters, 155(2), 132-135. https://doi.org/10.1016/0304-3940(93)90690-M

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10.1016/0304-3940(93)90690-M