Abstract
Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 132-135 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 155 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 11 1993 |
Keywords
- Basal ganglia
- Glutamate release
- Membrane current
- Platelet-activating factor
- Presynaptic inhibition
- Synaptic transmission
ASJC Scopus subject areas
- Neuroscience(all)
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Jiang, Z. G., Yue, T. L., & Feuerstein, G. (1993). Platelet-activating factor inhibits excitatory transmission in rat neostriatum. Neuroscience Letters, 155(2), 132-135. https://doi.org/10.1016/0304-3940(93)90690-M