Plasticity in the Aging Brain: Reversibility of Anatomic, Metabolic, and Cognitive Deficits in Normal-Pressure Hydrocephalus Following Shunt Surgery

Jeffrey Kaye, Cheryl L. Grady, James V. Haxby, Angela Moore, Robert P. Friedland

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The course of idiopathic normal-pressure hydrocephalus was studied in a 78-year-old woman with a 4-year history of progressive dementia who underwent neuropsychologic testing, quantitative x-ray computed tomography, magnetic resonance imaging, and positron emission tomography with fludeoxyglucose F 18 to measure rates of regional cerebral glucose utilization. Preshunt cognitive testing demonstrated progressive deterioration during 2 years, and positron emission tomography showed significant reductions in regional cerebral glucose utilization of 34% to 49% as compared with age-and sex-matched control subjects in frontal, temporal, parietal, and whole brain regions. Periodic testing, carried out during a 2-year period after shunt surgery, showed steady improvement in clinical status. Parallel to the clinical changes, there was a significant reversal in neuropsychologic test scores with increased brain volume and increased regional cerebral glucose utilization in several brain regions. These results documented the considerable potential for recovery of compromised brain function in older subjects even after 4 years of progressive brain disease.

Original languageEnglish (US)
Pages (from-to)1336-1341
Number of pages6
JournalArchives of Neurology
Volume47
Issue number12
DOIs
StatePublished - 1990

Fingerprint

Normal Pressure Hydrocephalus
Brain
Glucose
Positron-Emission Tomography
Neuropsychological Tests
Fluorodeoxyglucose F18
Brain Diseases
Dementia
Tomography
Magnetic Resonance Imaging
X-Rays
Hydrocephalus
Reversibility
Surgery
Plasticity
Testing

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Plasticity in the Aging Brain : Reversibility of Anatomic, Metabolic, and Cognitive Deficits in Normal-Pressure Hydrocephalus Following Shunt Surgery. / Kaye, Jeffrey; Grady, Cheryl L.; Haxby, James V.; Moore, Angela; Friedland, Robert P.

In: Archives of Neurology, Vol. 47, No. 12, 1990, p. 1336-1341.

Research output: Contribution to journalArticle

Kaye, Jeffrey ; Grady, Cheryl L. ; Haxby, James V. ; Moore, Angela ; Friedland, Robert P. / Plasticity in the Aging Brain : Reversibility of Anatomic, Metabolic, and Cognitive Deficits in Normal-Pressure Hydrocephalus Following Shunt Surgery. In: Archives of Neurology. 1990 ; Vol. 47, No. 12. pp. 1336-1341.
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