Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis

Riad Lutfi, Jennifer Huang, Hector R. Wong

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A 10-year-old girl presented with diabetic ketoacidosis, shock, and severe abdominal pain. She was found to have acute pancreatitis and acute kidney injury after shock resuscitation and severe persistent hypertriglyceridemia. The severe hypertriglyceridemia was treated with 1 course of plasmapheresis, which corrected the triglyceride level and was temporally associated with improvement of the abdominal pain and renal dysfunction. Diabetes is known to contribute to an elevated triglyceride level, especially in the setting of an underlying lipid disorder. However, no such disorders were found in this patient. To the best of our knowledge, this is the first report of a pediatric patient presenting with the triad of severe hypertriglyceridemia, diabetic ketoacidosis, and pancreatitis treated successfully with plasmapheresis.

Original languageEnglish (US)
JournalPediatrics
Volume129
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Diabetic Ketoacidosis
Plasmapheresis
Hypertriglyceridemia
Pancreatitis
Abdominal Pain
Shock
Triglycerides
Acute Kidney Injury
Resuscitation
Pediatrics
Kidney
Lipids
Pain
Diabetes
Triad

Keywords

  • Acute pancreatitis
  • Diabetic ketoacidosis
  • Hyperlipidemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

Cite this

Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis. / Lutfi, Riad; Huang, Jennifer; Wong, Hector R.

In: Pediatrics, Vol. 129, No. 1, 01.2012.

Research output: Contribution to journalArticle

@article{75a617ca327a4aa38447899914bf8e10,
title = "Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis",
abstract = "A 10-year-old girl presented with diabetic ketoacidosis, shock, and severe abdominal pain. She was found to have acute pancreatitis and acute kidney injury after shock resuscitation and severe persistent hypertriglyceridemia. The severe hypertriglyceridemia was treated with 1 course of plasmapheresis, which corrected the triglyceride level and was temporally associated with improvement of the abdominal pain and renal dysfunction. Diabetes is known to contribute to an elevated triglyceride level, especially in the setting of an underlying lipid disorder. However, no such disorders were found in this patient. To the best of our knowledge, this is the first report of a pediatric patient presenting with the triad of severe hypertriglyceridemia, diabetic ketoacidosis, and pancreatitis treated successfully with plasmapheresis.",
keywords = "Acute pancreatitis, Diabetic ketoacidosis, Hyperlipidemia",
author = "Riad Lutfi and Jennifer Huang and Wong, {Hector R.}",
year = "2012",
month = "1",
doi = "10.1542/peds.2011-0217",
language = "English (US)",
volume = "129",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1",

}

TY - JOUR

T1 - Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis

AU - Lutfi, Riad

AU - Huang, Jennifer

AU - Wong, Hector R.

PY - 2012/1

Y1 - 2012/1

N2 - A 10-year-old girl presented with diabetic ketoacidosis, shock, and severe abdominal pain. She was found to have acute pancreatitis and acute kidney injury after shock resuscitation and severe persistent hypertriglyceridemia. The severe hypertriglyceridemia was treated with 1 course of plasmapheresis, which corrected the triglyceride level and was temporally associated with improvement of the abdominal pain and renal dysfunction. Diabetes is known to contribute to an elevated triglyceride level, especially in the setting of an underlying lipid disorder. However, no such disorders were found in this patient. To the best of our knowledge, this is the first report of a pediatric patient presenting with the triad of severe hypertriglyceridemia, diabetic ketoacidosis, and pancreatitis treated successfully with plasmapheresis.

AB - A 10-year-old girl presented with diabetic ketoacidosis, shock, and severe abdominal pain. She was found to have acute pancreatitis and acute kidney injury after shock resuscitation and severe persistent hypertriglyceridemia. The severe hypertriglyceridemia was treated with 1 course of plasmapheresis, which corrected the triglyceride level and was temporally associated with improvement of the abdominal pain and renal dysfunction. Diabetes is known to contribute to an elevated triglyceride level, especially in the setting of an underlying lipid disorder. However, no such disorders were found in this patient. To the best of our knowledge, this is the first report of a pediatric patient presenting with the triad of severe hypertriglyceridemia, diabetic ketoacidosis, and pancreatitis treated successfully with plasmapheresis.

KW - Acute pancreatitis

KW - Diabetic ketoacidosis

KW - Hyperlipidemia

UR - http://www.scopus.com/inward/record.url?scp=84855271582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855271582&partnerID=8YFLogxK

U2 - 10.1542/peds.2011-0217

DO - 10.1542/peds.2011-0217

M3 - Article

C2 - 22201145

AN - SCOPUS:84855271582

VL - 129

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -