Plasma Transfusion

History, Current Realities and Novel Improvements

Justin J J Watson, Shibani Pati, Martin Schreiber

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    ABSTRACT: Traumatic hemorrhage is the leading cause of preventable death after trauma. Early transfusion of plasma and balanced transfusion have been shown to optimize survival, mitigate the acute coagulopathy of trauma and restore the endothelial glycocalyx. There are a myriad of plasma formulations available worldwide including: fresh frozen plasma, thawed plasma, liquid plasma, plasma frozen within 24?hours and lyophilized plasma. Significant equipoise exists in the literature regarding the optimal plasma formulation. Lyophilized plasma is a freeze dried formulation that was originally developed in the 1930ʼs and used by the American and British military in WW II. It was subsequently discontinued due to risk of disease transmission from pooled donors. Recently there has been significant research focusing on optimizing reconstitution of lyophilized plasma. Findings show sterile water buffered with ascorbic acid results in decreased blood loss with suppression of systemic inflammation. We are now beginning to realize the creation of a plasma-derived formulation that rapidly produces the associated benefits without logistical or safety constraints. This review will highlight the history of plasma, detail the various types of plasma formulations currently available, their pathophysiological effects and impacts of storage on coagulation factors in vitro and in vivo, novel concepts and future directions.

    Original languageEnglish (US)
    JournalShock
    DOIs
    StateAccepted/In press - Jul 1 2016

    Fingerprint

    History
    Glycocalyx
    Blood Coagulation Factors
    Wounds and Injuries
    Ascorbic Acid
    Cause of Death
    Hemorrhage
    Inflammation
    Safety
    Water

    ASJC Scopus subject areas

    • Emergency Medicine
    • Critical Care and Intensive Care Medicine

    Cite this

    Plasma Transfusion : History, Current Realities and Novel Improvements. / Watson, Justin J J; Pati, Shibani; Schreiber, Martin.

    In: Shock, 01.07.2016.

    Research output: Contribution to journalArticle

    @article{bf60a975aa7d40dba90a1b3ad4802310,
    title = "Plasma Transfusion: History, Current Realities and Novel Improvements",
    abstract = "ABSTRACT: Traumatic hemorrhage is the leading cause of preventable death after trauma. Early transfusion of plasma and balanced transfusion have been shown to optimize survival, mitigate the acute coagulopathy of trauma and restore the endothelial glycocalyx. There are a myriad of plasma formulations available worldwide including: fresh frozen plasma, thawed plasma, liquid plasma, plasma frozen within 24?hours and lyophilized plasma. Significant equipoise exists in the literature regarding the optimal plasma formulation. Lyophilized plasma is a freeze dried formulation that was originally developed in the 1930ʼs and used by the American and British military in WW II. It was subsequently discontinued due to risk of disease transmission from pooled donors. Recently there has been significant research focusing on optimizing reconstitution of lyophilized plasma. Findings show sterile water buffered with ascorbic acid results in decreased blood loss with suppression of systemic inflammation. We are now beginning to realize the creation of a plasma-derived formulation that rapidly produces the associated benefits without logistical or safety constraints. This review will highlight the history of plasma, detail the various types of plasma formulations currently available, their pathophysiological effects and impacts of storage on coagulation factors in vitro and in vivo, novel concepts and future directions.",
    author = "Watson, {Justin J J} and Shibani Pati and Martin Schreiber",
    year = "2016",
    month = "7",
    day = "1",
    doi = "10.1097/SHK.0000000000000663",
    language = "English (US)",
    journal = "Shock",
    issn = "1073-2322",
    publisher = "Lippincott Williams and Wilkins",

    }

    TY - JOUR

    T1 - Plasma Transfusion

    T2 - History, Current Realities and Novel Improvements

    AU - Watson, Justin J J

    AU - Pati, Shibani

    AU - Schreiber, Martin

    PY - 2016/7/1

    Y1 - 2016/7/1

    N2 - ABSTRACT: Traumatic hemorrhage is the leading cause of preventable death after trauma. Early transfusion of plasma and balanced transfusion have been shown to optimize survival, mitigate the acute coagulopathy of trauma and restore the endothelial glycocalyx. There are a myriad of plasma formulations available worldwide including: fresh frozen plasma, thawed plasma, liquid plasma, plasma frozen within 24?hours and lyophilized plasma. Significant equipoise exists in the literature regarding the optimal plasma formulation. Lyophilized plasma is a freeze dried formulation that was originally developed in the 1930ʼs and used by the American and British military in WW II. It was subsequently discontinued due to risk of disease transmission from pooled donors. Recently there has been significant research focusing on optimizing reconstitution of lyophilized plasma. Findings show sterile water buffered with ascorbic acid results in decreased blood loss with suppression of systemic inflammation. We are now beginning to realize the creation of a plasma-derived formulation that rapidly produces the associated benefits without logistical or safety constraints. This review will highlight the history of plasma, detail the various types of plasma formulations currently available, their pathophysiological effects and impacts of storage on coagulation factors in vitro and in vivo, novel concepts and future directions.

    AB - ABSTRACT: Traumatic hemorrhage is the leading cause of preventable death after trauma. Early transfusion of plasma and balanced transfusion have been shown to optimize survival, mitigate the acute coagulopathy of trauma and restore the endothelial glycocalyx. There are a myriad of plasma formulations available worldwide including: fresh frozen plasma, thawed plasma, liquid plasma, plasma frozen within 24?hours and lyophilized plasma. Significant equipoise exists in the literature regarding the optimal plasma formulation. Lyophilized plasma is a freeze dried formulation that was originally developed in the 1930ʼs and used by the American and British military in WW II. It was subsequently discontinued due to risk of disease transmission from pooled donors. Recently there has been significant research focusing on optimizing reconstitution of lyophilized plasma. Findings show sterile water buffered with ascorbic acid results in decreased blood loss with suppression of systemic inflammation. We are now beginning to realize the creation of a plasma-derived formulation that rapidly produces the associated benefits without logistical or safety constraints. This review will highlight the history of plasma, detail the various types of plasma formulations currently available, their pathophysiological effects and impacts of storage on coagulation factors in vitro and in vivo, novel concepts and future directions.

    UR - http://www.scopus.com/inward/record.url?scp=84977160704&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84977160704&partnerID=8YFLogxK

    U2 - 10.1097/SHK.0000000000000663

    DO - 10.1097/SHK.0000000000000663

    M3 - Article

    JO - Shock

    JF - Shock

    SN - 1073-2322

    ER -