Plasma steroids in congenital adrenal hyperplasia

Donald (Lynn) Loriaux, H. J. Ruder, M. B. Lipsett

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Plasma concentrations of dehydroepiandrosterone, 17-hydroxypregnenolone, Δ5-androstenediol, 17-hydroxyprogesterone, progesterone, cortisol and 21-deoxycortisol were measured in 8 patients with the 21-hydroxylase deficiency type of congenital adrenal hyperplasia. In contrast to 17-hydroxyprogesterone, which was elevated as much as 100 fold, the Δ5 steroids were elevated only about 2 fold when compared to normal adult values. Plasma progesterone in 3 salt losing siblings was about 5 times that of the nonsalt losing subjects. Plasma 21 deoxycortisol averaged about 25 ng/ml, compared to an average of 0.3 ng/ml in normal subjects.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume39
Issue number4
StatePublished - 1974
Externally publishedYes

Fingerprint

Congenital Adrenal Hyperplasia
17-alpha-Hydroxyprogesterone
Steroids
Plasmas
Progesterone
17-alpha-Hydroxypregnenolone
Androstenediol
Steroid 21-Hydroxylase
Dehydroepiandrosterone
Hydrocortisone
Siblings
Reference Values
Salts
21-deoxycortisol

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma steroids in congenital adrenal hyperplasia. / Loriaux, Donald (Lynn); Ruder, H. J.; Lipsett, M. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 39, No. 4, 1974, p. 627-630.

Research output: Contribution to journalArticle

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