Plasma steroids in congenital adrenal hyperplasia

D. L. Loriaux, H. J. Ruder, M. B. Lipsett

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Plasma concentrations of dehydroepiandrosterone, 17-hydroxypregnenolone, Δ5- androstenediol, 17-hydroxyprogesterone, progesterone, cortisol and 21-deoxycortisol were measured in 8 patients with the 21-hydroxylase deficiency type of congenital adrenal hyperplasia. In contrast to 17-hydroxyprogesterone, which was elevated as much as 100-fold, the Δ5-steroids were elevated only about 2-fold when compared to normal adult values. Plasma progesterone in 3 salt-losing siblings was about 5 times that of the nonsalt-losing subjects. Plasma 21-deoxycortisol averaged about 25 ng/ml, compared to an average of 0.3 ng/ml in normal subjects.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume39
Issue number4
DOIs
StatePublished - Oct 1974

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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