Plasma renin activity responses to graded decreases in renal perfusion pressure in fetal and newborn lambs

N. D. Binder, Debra Anderson

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    We examined the relationship between acute reductions in renal perfusion pressure, as approximated by femoral arterial blood pressure, and plasma renin activity in the uninephrectomized fetal lamb. Renal perfusion pressure was reduced and maintained at a constant value by controlled partial occlusion of the aorta above the renal artery. After 15 min of reduced blood pressure, blood samples were taken for determination of plasma renin activity. This protocol was performed 22 times in 11 fetal lambs. Additionally, three of the fetuses were delivered by cesarean section and studied as newborns for the first week of life. In the fetus, there was a linear relationship between log plasma renin activity and femoral arterial blood pressure (P <0.01). After birth, the relationship still existed, although it was shifted to the right (P <0.0001). We conclude that there is a significant relationship between plasma renin activity and renal perfusion pressure in the fetal lamb, and as early as 1 day after birth, this relationship shifts to the right in the newborn lamb.

    Original languageEnglish (US)
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume262
    Issue number3 31-3
    StatePublished - 1992

    Fingerprint

    Renin
    Perfusion
    Kidney
    Pressure
    Thigh
    Arterial Pressure
    Fetus
    Parturition
    Renal Artery
    Cesarean Section
    Aorta
    Blood Pressure

    Keywords

    • fetal blood pressure
    • renal baroreceptor
    • renal stimulus-response curves

    ASJC Scopus subject areas

    • Physiology

    Cite this

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    AU - Binder, N. D.

    AU - Anderson, Debra

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