TY - JOUR
T1 - Plasma renin activity responses to graded decreases in renal perfusion pressure in fetal and newborn lambs
AU - Binder, N. D.
AU - Anderson, D. F.
PY - 1992
Y1 - 1992
N2 - We examined the relationship between acute reductions in renal perfusion pressure, as approximated by femoral arterial blood pressure, and plasma renin activity in the uninephrectomized fetal lamb. Renal perfusion pressure was reduced and maintained at a constant value by controlled partial occlusion of the aorta above the renal artery. After 15 min of reduced blood pressure, blood samples were taken for determination of plasma renin activity. This protocol was performed 22 times in 11 fetal lambs. Additionally, three of the fetuses were delivered by cesarean section and studied as newborns for the first week of life. In the fetus, there was a linear relationship between log plasma renin activity and femoral arterial blood pressure (P < 0.01). After birth, the relationship still existed, although it was shifted to the right (P < 0.0001). We conclude that there is a significant relationship between plasma renin activity and renal perfusion pressure in the fetal lamb, and as early as 1 day after birth, this relationship shifts to the right in the newborn lamb.
AB - We examined the relationship between acute reductions in renal perfusion pressure, as approximated by femoral arterial blood pressure, and plasma renin activity in the uninephrectomized fetal lamb. Renal perfusion pressure was reduced and maintained at a constant value by controlled partial occlusion of the aorta above the renal artery. After 15 min of reduced blood pressure, blood samples were taken for determination of plasma renin activity. This protocol was performed 22 times in 11 fetal lambs. Additionally, three of the fetuses were delivered by cesarean section and studied as newborns for the first week of life. In the fetus, there was a linear relationship between log plasma renin activity and femoral arterial blood pressure (P < 0.01). After birth, the relationship still existed, although it was shifted to the right (P < 0.0001). We conclude that there is a significant relationship between plasma renin activity and renal perfusion pressure in the fetal lamb, and as early as 1 day after birth, this relationship shifts to the right in the newborn lamb.
KW - fetal blood pressure
KW - renal baroreceptor
KW - renal stimulus-response curves
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U2 - 10.1152/ajpregu.1992.262.3.r524
DO - 10.1152/ajpregu.1992.262.3.r524
M3 - Article
C2 - 1558222
AN - SCOPUS:0026553052
SN - 0002-9513
VL - 262
SP - R524-R529
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 3 31-3
ER -