Plasma reactive nitrogen intermediate levels in patients with clinically active rheumatoid arthritis

A. Wanchu, N. Agnihotri, S. D. Deodhar, N. K. Ganguly

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8 Scopus citations

Abstract

We studied reactive nitrogen intermediate levels in 31 patients with active rheumatoid arthritis (RA) ,taking indomethacin and 20 healthy controls using nitrite and citrulline levels, measured by spectrophotometry, as markers. Twenty patients with RA were followed up after 4 and 8 wk of treatment with additional therapy in the form of methotrexate. Mean nitrite levels in 31 patients were 0.94 ± 0.41 μmol/ml and 20 controls it was 1.18 ± 0.99. After treatment with methotrexate for 4 and 8 wk the levels were 0.9 ± 0.45 and 1.25 ± 1.15 μmol/ml, respectively. Mean citrulline levels in all patients was 1.68 ± 0.11 and controls was 1.39 ± 0.6 μmol/ml. Following therapy with methotrexate for 4 and 8 wk the levels were 1.40 ± 0.49 and 1.40 ± 0.51 μmol/ml, respectively. It is possible that serum levels of these products may not reflect alterations in the synovial fluid levels. Alternatively, whatever lowering may have been achieved by the anti-inflammatory effect of the therapy may have been countered by drug derived free radicals.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalIndian Journal of Medical Research
Volume104
Issue numberOCT
StatePublished - Oct 1 1996

Keywords

  • Citrulline
  • Indomethacin
  • Methotrexate
  • Nitrite
  • Reactive nitrogen intermediates
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Wanchu, A., Agnihotri, N., Deodhar, S. D., & Ganguly, N. K. (1996). Plasma reactive nitrogen intermediate levels in patients with clinically active rheumatoid arthritis. Indian Journal of Medical Research, 104(OCT), 263-268.