TY - JOUR
T1 - Plasma lipids and hypertension
T2 - Response to calcium supplementation
AU - Karanja, N.
AU - Morris, C. D.
AU - Illingworth, D. R.
AU - McCarron, D. A.
PY - 1987
Y1 - 1987
N2 - Evidence from animal and human studies indicate that calcium supplementation may ameliorate two risk factors for atherosclerotic cardiovascular disease, hypertension and hyperlipidemia. We sought to characterize dietary fat consumption and plasma lipid profiles in hypertensive and normotensive subjects and plasma lipid responses to supplemental calcium. A randomized, double-blind, placebo-controlled, crossover protocol was used to assess blood pressure and lipid response to 8 wk of 1000 mg of elemental calcium in 43 hypertensive and 27 normotensive subjects. Nutrient intakes and plasma lipids were measured repeatedly. Hypertensive female subjects consumed significantly less (p < 0.05) phosphorus, potassium, and magnesium and had significantly higher triglycerides (p < 0.04) and lower HDL-cholesterol (p < 0.02) than did normotensive subjects. There were no significant changes in dietary plasma lipids with calcium supplementation. Mildly hyperlipidemic normotensive subjects had a significant decrease in total cholesterol (p < 0.05). No significant changes in plasma occurred with calcium supplementation in hypertensive subjects.
AB - Evidence from animal and human studies indicate that calcium supplementation may ameliorate two risk factors for atherosclerotic cardiovascular disease, hypertension and hyperlipidemia. We sought to characterize dietary fat consumption and plasma lipid profiles in hypertensive and normotensive subjects and plasma lipid responses to supplemental calcium. A randomized, double-blind, placebo-controlled, crossover protocol was used to assess blood pressure and lipid response to 8 wk of 1000 mg of elemental calcium in 43 hypertensive and 27 normotensive subjects. Nutrient intakes and plasma lipids were measured repeatedly. Hypertensive female subjects consumed significantly less (p < 0.05) phosphorus, potassium, and magnesium and had significantly higher triglycerides (p < 0.04) and lower HDL-cholesterol (p < 0.02) than did normotensive subjects. There were no significant changes in dietary plasma lipids with calcium supplementation. Mildly hyperlipidemic normotensive subjects had a significant decrease in total cholesterol (p < 0.05). No significant changes in plasma occurred with calcium supplementation in hypertensive subjects.
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U2 - 10.1093/ajcn/45.1.60
DO - 10.1093/ajcn/45.1.60
M3 - Article
C2 - 3799505
AN - SCOPUS:0023128455
SN - 0002-9165
VL - 45
SP - 60
EP - 65
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -