Plasma lipid levels and colorectal adenoma risk

John Anthony Coppola, Martha J. Shrubsole, Qiuyin Cai, Walter E. Smalley, Qi Dai, Reid M. Ness, Sergio Fazio, Wei Zheng, Harvey J. Murff

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    Purpose: Abnormalities in lipid levels have been associated with colorectal neoplasm risk; however, few studies have adjusted for use of cholesterol-lowering medications. The objective of this study was to determine the association of plasma lipid levels with adenoma risk while accounting for statin medication use.

    Methods: We included 254 subjects with advanced adenoma, 246 with single small adenoma, 179 with multiple small adenoma cases, and 403 control participants in the Tennessee Colorectal Polyp Study who also had plasma lipid measurements performed. Data on the use of statin medications were available for 83.4 % of these participants. The association between plasma lipids and adenoma risk was evaluated using logistic regression models.

    Results: Participants in the highest quartile of HDL cholesterol (range 52–106 mg/dl) had an adjusted odds ratio of 0.49 (95 % CI 0.23, 1.07), 0.35 (95 % CI 0.13, 0.91), and 0.22 (95 % CI 0.09, 0.54) for single small, multiple small, and advanced adenomas compared to the lowest quartile (range 12–34 mg/dl), respectively. Participants with the highest quartile of triglyceride levels (range 178–721 mg/dl) had an adjusted odds ratio of 2.40 (95 % CI 1.26, 4.55), 1.67 (95 % CI 0.66, 4.23), and 2.79 (95 % CI 1.25, 6.23) for single small, multiple small, and advanced adenoma, respectively, compared to the lowest quartile (range 40–84 mg/dl). When restricted to individuals with known statin medication use, adjusting for statin use did not appreciably affect these results.

    Conclusion: We found a direct association between triglyceride plasma levels and an inverse association between plasma HDL cholesterol levels and adenoma risk. Both effects were not appreciably changed when accounting for the regular use of statin medication.

    Original languageEnglish (US)
    Pages (from-to)635-643
    Number of pages9
    JournalCancer Causes and Control
    Volume26
    Issue number4
    DOIs
    StatePublished - Jan 1 2015

    Keywords

    • Colorectal
    • Hypolipidemic agents
    • Lipoproteins
    • Neoplasms

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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  • Cite this

    Coppola, J. A., Shrubsole, M. J., Cai, Q., Smalley, W. E., Dai, Q., Ness, R. M., Fazio, S., Zheng, W., & Murff, H. J. (2015). Plasma lipid levels and colorectal adenoma risk. Cancer Causes and Control, 26(4), 635-643. https://doi.org/10.1007/s10552-015-0555-y