Plasma cell survival in the absence of B cell memory

Erika Hammarlund, Archana Thomas, Ian J. Amanna, Lindsay A. Holden, Ov Slayden, Byung Park, Lina Gao, Mark Slifka

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Pre-existing serum antibodies play an important role in vaccine-mediated protection against infection but the underlying mechanisms of immune memory are unclear. Clinical studies indicate that antigen-specific antibody responses can be maintained for many years, leading to theories that reactivation/differentiation of memory B cells into plasma cells is required to sustain long-term antibody production. Here, we present a decade-long study in which we demonstrate site-specific survival of bone marrow-derived plasma cells and durable antibody responses to multiple virus and vaccine antigens in rhesus macaques for years after sustained memory B cell depletion. Moreover, BrdU+ cells with plasma cell morphology can be detected for 10 years after vaccination/BrdU administration, indicating that plasma cells may persist for a prolonged period of time in the absence of cell division. On the basis of these results, long-lived plasma cells represent a key cell population responsible for long-term antibody production and serological memory.

Original languageEnglish (US)
Article number1781
JournalNature Communications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Plasma Cells
Cell Survival
antibodies
B-Lymphocytes
Cells
Antibody Formation
Plasmas
Data storage equipment
Antibodies
cells
vaccines
Bromodeoxyuridine
antigens
Vaccines
Antigens
cell division
Macaca mulatta
Viruses
bone marrow
Cell Division

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Plasma cell survival in the absence of B cell memory. / Hammarlund, Erika; Thomas, Archana; Amanna, Ian J.; Holden, Lindsay A.; Slayden, Ov; Park, Byung; Gao, Lina; Slifka, Mark.

In: Nature Communications, Vol. 8, No. 1, 1781, 01.12.2017.

Research output: Contribution to journalArticle

Hammarlund, Erika ; Thomas, Archana ; Amanna, Ian J. ; Holden, Lindsay A. ; Slayden, Ov ; Park, Byung ; Gao, Lina ; Slifka, Mark. / Plasma cell survival in the absence of B cell memory. In: Nature Communications. 2017 ; Vol. 8, No. 1.
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