Plasma catecholamine and free fatty acid levels during infusion of lipid emulsion in critically ill patients

M. Lindholm; J. O. Eklund; B. Hamberger; P. O. Jarnberg

doi:10.1097/00003246-198411000-00006

Plasma catecholamine and free fatty acid levels during infusion of lipid emulsion in critically ill patients

M. Lindholm, J. O. Eklund, B. Hamberger, P. O. Jarnberg

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The fractional elimination rate of exogenous fat, and fat-mobilizing lipolysis in relation to plasma catecholamine (CA) levels were studied in seven ventilator-treated ICU patients. Blood levels of CA, triglycerides, cholesterol and free fatty acids (FFA) were also analyzed before and during constant infusion of a soybean oil emulsion (Intralipid). Triglyceride concentrations rose significantly during the infusion. FFA levels also increased significantly within 30 min after the infusion was begun, reflecting fatty acids derived from Intralipid triglycerides. Plasma norepinephrine levels showed large interindividual variations and were inversely related to FFA concentrations. No correlation was found between plasma CA levels and the fractional removal rate of fat. These data suggest a deficiency of substrate in these critically ill patients.

Original language	English (US)
Pages (from-to)	953-956
Number of pages	4
Journal	Critical care medicine
Volume	12
Issue number	11
DOIs	https://doi.org/10.1097/00003246-198411000-00006
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1097/00003246-198411000-00006

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abstract = "The fractional elimination rate of exogenous fat, and fat-mobilizing lipolysis in relation to plasma catecholamine (CA) levels were studied in seven ventilator-treated ICU patients. Blood levels of CA, triglycerides, cholesterol and free fatty acids (FFA) were also analyzed before and during constant infusion of a soybean oil emulsion (Intralipid). Triglyceride concentrations rose significantly during the infusion. FFA levels also increased significantly within 30 min after the infusion was begun, reflecting fatty acids derived from Intralipid triglycerides. Plasma norepinephrine levels showed large interindividual variations and were inversely related to FFA concentrations. No correlation was found between plasma CA levels and the fractional removal rate of fat. These data suggest a deficiency of substrate in these critically ill patients.",

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AU - Lindholm, M.

AU - Eklund, J. O.

AU - Hamberger, B.

AU - Jarnberg, P. O.

PY - 1984

Y1 - 1984

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AB - The fractional elimination rate of exogenous fat, and fat-mobilizing lipolysis in relation to plasma catecholamine (CA) levels were studied in seven ventilator-treated ICU patients. Blood levels of CA, triglycerides, cholesterol and free fatty acids (FFA) were also analyzed before and during constant infusion of a soybean oil emulsion (Intralipid). Triglyceride concentrations rose significantly during the infusion. FFA levels also increased significantly within 30 min after the infusion was begun, reflecting fatty acids derived from Intralipid triglycerides. Plasma norepinephrine levels showed large interindividual variations and were inversely related to FFA concentrations. No correlation was found between plasma CA levels and the fractional removal rate of fat. These data suggest a deficiency of substrate in these critically ill patients.

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Plasma catecholamine and free fatty acid levels during infusion of lipid emulsion in critically ill patients

Abstract

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