Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus

L. Stankova, M. Riddle, J. Larned, K. Burry, Victor Menashe, J. Hart, R. Bigley

Research output: Contribution to journalArticle

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Abstract

Rates of dehydroascorbate uptake by blood granulocytes and mononuclear cells are slower, and plasma ascorbate concentrations are lower, among persons with diabetes mellitus than in nondiabetic subjects. These measurements do not correlate with one another or with simultaneously measured plasma glucose or glycosylated hemoglobin; they do not differ with type of diabetes or mode of treatment. In those diabetic granulocytes that exhibit slow dehydroascorbate uptake, maximal velocity (Vmax) transport rates for dehydroascorbate, 2-deoxyglucose, and 3-O-methylglucose are decreased, each to the same degree, while Km values for transport of these ligands are not different from those observed in nondiabetic cells. Since diffusion of these ligands is facilitated by a common transporter, these observations may reflect decreased numbers of glucose transporters in the plasma membranes of some diabetic leukocytes.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalMetabolism
Volume33
Issue number4
DOIs
StatePublished - 1984

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Granulocytes
Blood Cells
Diabetes Mellitus
3-O-Methylglucose
Ligands
Facilitative Glucose Transport Proteins
Deoxyglucose
Glycosylated Hemoglobin A
Plasma Cells
Leukocytes
Cell Membrane
Glucose
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Stankova, L., Riddle, M., Larned, J., Burry, K., Menashe, V., Hart, J., & Bigley, R. (1984). Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus. Metabolism, 33(4), 347-353. https://doi.org/10.1016/0026-0495(84)90197-5

Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus. / Stankova, L.; Riddle, M.; Larned, J.; Burry, K.; Menashe, Victor; Hart, J.; Bigley, R.

In: Metabolism, Vol. 33, No. 4, 1984, p. 347-353.

Research output: Contribution to journalArticle

Stankova, L, Riddle, M, Larned, J, Burry, K, Menashe, V, Hart, J & Bigley, R 1984, 'Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus', Metabolism, vol. 33, no. 4, pp. 347-353. https://doi.org/10.1016/0026-0495(84)90197-5
Stankova, L. ; Riddle, M. ; Larned, J. ; Burry, K. ; Menashe, Victor ; Hart, J. ; Bigley, R. / Plasma ascorbate concentrations and blood cell dehydroascorbate transport in patients with diabetes mellitus. In: Metabolism. 1984 ; Vol. 33, No. 4. pp. 347-353.
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