Plasma albumin repletion after transfusion with polymerized hemoglobin

Richard Mullins, Mark Wehry, Russel Hudgins, Richard Rink

    Research output: Contribution to journalArticle

    Abstract

    Pyridoxalated polymerized hemoglobin (PPHG) has promise as a blood substitute for transfusing patients with hemorrhage. Exchange transfusion with PPHG depletes plasma proteins. The purpose of this study was to determine if, during the early repletion of intravascular proteins, albumin was transported from the interstitium of skin or skeletal muscle into the vascular compartment. PPHG was prepared from stroma-free human hemoglobin (100-120 mg/ml). The Hct of anesthetized rats dropped from 42 ± 4% to 10 ± 1% after exchange transfusion. Immediately postexchange plasma albumin declined from 24 ± 2 to 6 ± 3 mg/ml. Five hours postexchange transfusion plasma albumin had doubled and the skin and skeletal muscle albumin content was 80% of control. These data indicate that a shift of interstitial albumin from skin and skeletal muscle can rapidly replace plasma protein deficits after massive transfusion with PPHG.

    Original languageEnglish (US)
    Pages (from-to)441-446
    Number of pages6
    JournalJournal of Surgical Research
    Volume49
    Issue number5
    DOIs
    StatePublished - Nov 1990

    ASJC Scopus subject areas

    • Surgery

    Fingerprint Dive into the research topics of 'Plasma albumin repletion after transfusion with polymerized hemoglobin'. Together they form a unique fingerprint.

  • Cite this