Plasma albumin repletion after transfusion with polymerized hemoglobin

Richard Mullins, Mark Wehry, Russel Hudgins, Richard Rink

Research output: Contribution to journalArticle

Abstract

Pyridoxalated polymerized hemoglobin (PPHG) has promise as a blood substitute for transfusing patients with hemorrhage. Exchange transfusion with PPHG depletes plasma proteins. The purpose of this study was to determine if, during the early repletion of intravascular proteins, albumin was transported from the interstitium of skin or skeletal muscle into the vascular compartment. PPHG was prepared from stroma-free human hemoglobin (100-120 mg/ml). The Hct of anesthetized rats dropped from 42 ± 4% to 10 ± 1% after exchange transfusion. Immediately postexchange plasma albumin declined from 24 ± 2 to 6 ± 3 mg/ml. Five hours postexchange transfusion plasma albumin had doubled and the skin and skeletal muscle albumin content was 80% of control. These data indicate that a shift of interstitial albumin from skin and skeletal muscle can rapidly replace plasma protein deficits after massive transfusion with PPHG.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalJournal of Surgical Research
Volume49
Issue number5
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Serum Albumin
Hemoglobins
Albumins
Skeletal Muscle
Skin
Blood Proteins
Blood Substitutes
Blood Vessels
Hemorrhage
polyhemoglobin-pyridoxal-5-phosphate
Proteins

ASJC Scopus subject areas

  • Surgery

Cite this

Plasma albumin repletion after transfusion with polymerized hemoglobin. / Mullins, Richard; Wehry, Mark; Hudgins, Russel; Rink, Richard.

In: Journal of Surgical Research, Vol. 49, No. 5, 1990, p. 441-446.

Research output: Contribution to journalArticle

Mullins, Richard ; Wehry, Mark ; Hudgins, Russel ; Rink, Richard. / Plasma albumin repletion after transfusion with polymerized hemoglobin. In: Journal of Surgical Research. 1990 ; Vol. 49, No. 5. pp. 441-446.
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