Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome

Masayuki Shinahara, Mitsuru Nishiyama, Yasumasa Iwasaki, Shuichi Nakayama, Toru Noguchi, Machiko Kambayashi, Yasushi Okada, Masayuki Tsuda, Mary Stenzel-Poore, Kozo Hashimoto, Yoshio Terada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Adiponectin (AdN), an adipokine derived from the adipose tissue, has an insulin-sensitizing effect, and plasma AdN is shown to be decreased in obesity and/or insulin resistant state. To clarify whether changes in AdN are also responsible for the development of glucocorticoid-induced insulin resistance, we examined AdN concentration in plasma and AdN expression in the adipose tissue, using corticotropin-releasing hormone (CRH) transgenic mouse (CRH-Tg), an animal model of Cushing syndrome. We found, unexpectedly, that plasma AdN levels in CRH-Tg were significantly higher than those in wild-type littermates (wild-type: 19.7±2.5, CRH-Tg: 32.4±3.1μg/mL, p

Original languageEnglish (US)
Pages (from-to)879-886
Number of pages8
JournalEndocrine Journal
Volume56
Issue number7
DOIs
StatePublished - 2009

Fingerprint

Genetically Modified Animals
Cushing Syndrome
Corticotropin-Releasing Hormone
Adiponectin
Transgenic Mice
Insulin Resistance
Animal Models
Adipose Tissue
Insulin
Adipokines
Glucocorticoids
Obesity

Keywords

  • Adiponectin
  • Cushing syndrome
  • Glucocorticoid
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome. / Shinahara, Masayuki; Nishiyama, Mitsuru; Iwasaki, Yasumasa; Nakayama, Shuichi; Noguchi, Toru; Kambayashi, Machiko; Okada, Yasushi; Tsuda, Masayuki; Stenzel-Poore, Mary; Hashimoto, Kozo; Terada, Yoshio.

In: Endocrine Journal, Vol. 56, No. 7, 2009, p. 879-886.

Research output: Contribution to journalArticle

Shinahara, M, Nishiyama, M, Iwasaki, Y, Nakayama, S, Noguchi, T, Kambayashi, M, Okada, Y, Tsuda, M, Stenzel-Poore, M, Hashimoto, K & Terada, Y 2009, 'Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome', Endocrine Journal, vol. 56, no. 7, pp. 879-886. https://doi.org/10.1507/endocrj.K09E-038
Shinahara, Masayuki ; Nishiyama, Mitsuru ; Iwasaki, Yasumasa ; Nakayama, Shuichi ; Noguchi, Toru ; Kambayashi, Machiko ; Okada, Yasushi ; Tsuda, Masayuki ; Stenzel-Poore, Mary ; Hashimoto, Kozo ; Terada, Yoshio. / Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome. In: Endocrine Journal. 2009 ; Vol. 56, No. 7. pp. 879-886.
@article{03135d16286e45e5b2a040fa1035a3fa,
title = "Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome",
abstract = "Adiponectin (AdN), an adipokine derived from the adipose tissue, has an insulin-sensitizing effect, and plasma AdN is shown to be decreased in obesity and/or insulin resistant state. To clarify whether changes in AdN are also responsible for the development of glucocorticoid-induced insulin resistance, we examined AdN concentration in plasma and AdN expression in the adipose tissue, using corticotropin-releasing hormone (CRH) transgenic mouse (CRH-Tg), an animal model of Cushing syndrome. We found, unexpectedly, that plasma AdN levels in CRH-Tg were significantly higher than those in wild-type littermates (wild-type: 19.7±2.5, CRH-Tg: 32.4±3.1μg/mL, p",
keywords = "Adiponectin, Cushing syndrome, Glucocorticoid, Insulin resistance, Obesity",
author = "Masayuki Shinahara and Mitsuru Nishiyama and Yasumasa Iwasaki and Shuichi Nakayama and Toru Noguchi and Machiko Kambayashi and Yasushi Okada and Masayuki Tsuda and Mary Stenzel-Poore and Kozo Hashimoto and Yoshio Terada",
year = "2009",
doi = "10.1507/endocrj.K09E-038",
language = "English (US)",
volume = "56",
pages = "879--886",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "7",

}

TY - JOUR

T1 - Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome

AU - Shinahara, Masayuki

AU - Nishiyama, Mitsuru

AU - Iwasaki, Yasumasa

AU - Nakayama, Shuichi

AU - Noguchi, Toru

AU - Kambayashi, Machiko

AU - Okada, Yasushi

AU - Tsuda, Masayuki

AU - Stenzel-Poore, Mary

AU - Hashimoto, Kozo

AU - Terada, Yoshio

PY - 2009

Y1 - 2009

N2 - Adiponectin (AdN), an adipokine derived from the adipose tissue, has an insulin-sensitizing effect, and plasma AdN is shown to be decreased in obesity and/or insulin resistant state. To clarify whether changes in AdN are also responsible for the development of glucocorticoid-induced insulin resistance, we examined AdN concentration in plasma and AdN expression in the adipose tissue, using corticotropin-releasing hormone (CRH) transgenic mouse (CRH-Tg), an animal model of Cushing syndrome. We found, unexpectedly, that plasma AdN levels in CRH-Tg were significantly higher than those in wild-type littermates (wild-type: 19.7±2.5, CRH-Tg: 32.4±3.1μg/mL, p

AB - Adiponectin (AdN), an adipokine derived from the adipose tissue, has an insulin-sensitizing effect, and plasma AdN is shown to be decreased in obesity and/or insulin resistant state. To clarify whether changes in AdN are also responsible for the development of glucocorticoid-induced insulin resistance, we examined AdN concentration in plasma and AdN expression in the adipose tissue, using corticotropin-releasing hormone (CRH) transgenic mouse (CRH-Tg), an animal model of Cushing syndrome. We found, unexpectedly, that plasma AdN levels in CRH-Tg were significantly higher than those in wild-type littermates (wild-type: 19.7±2.5, CRH-Tg: 32.4±3.1μg/mL, p

KW - Adiponectin

KW - Cushing syndrome

KW - Glucocorticoid

KW - Insulin resistance

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=70350676818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350676818&partnerID=8YFLogxK

U2 - 10.1507/endocrj.K09E-038

DO - 10.1507/endocrj.K09E-038

M3 - Article

C2 - 19550079

AN - SCOPUS:70350676818

VL - 56

SP - 879

EP - 886

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 7

ER -