Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Louis S. Bouchard, M. Sabieh Anwar, Gang L. Liu, Byron Hann, Z. Harry Xie, Joe Gray, Xueding Wang, Alexander Pines, Fanqing Frank Chen

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

Original languageEnglish (US)
Pages (from-to)4085-4089
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number11
DOIs
StatePublished - Mar 17 2009
Externally publishedYes

Fingerprint

Cobalt
Nanoparticles
Tomography
Gold

Keywords

  • Dual-modality imaging
  • Ferromagnetic nanoparticle molecular imaging
  • MRI contrast
  • Photoacoustic tomography

ASJC Scopus subject areas

  • General

Cite this

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles. / Bouchard, Louis S.; Anwar, M. Sabieh; Liu, Gang L.; Hann, Byron; Xie, Z. Harry; Gray, Joe; Wang, Xueding; Pines, Alexander; Chen, Fanqing Frank.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 11, 17.03.2009, p. 4085-4089.

Research output: Contribution to journalArticle

Bouchard, Louis S. ; Anwar, M. Sabieh ; Liu, Gang L. ; Hann, Byron ; Xie, Z. Harry ; Gray, Joe ; Wang, Xueding ; Pines, Alexander ; Chen, Fanqing Frank. / Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles. In: Proceedings of the National Academy of Sciences of the United States of America. 2009 ; Vol. 106, No. 11. pp. 4085-4089.
@article{f8a987e7241846bca7cbfac585041446,
title = "Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles",
abstract = "Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.",
keywords = "Dual-modality imaging, Ferromagnetic nanoparticle molecular imaging, MRI contrast, Photoacoustic tomography",
author = "Bouchard, {Louis S.} and Anwar, {M. Sabieh} and Liu, {Gang L.} and Byron Hann and Xie, {Z. Harry} and Joe Gray and Xueding Wang and Alexander Pines and Chen, {Fanqing Frank}",
year = "2009",
month = "3",
day = "17",
doi = "10.1073/pnas.0813019106",
language = "English (US)",
volume = "106",
pages = "4085--4089",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "11",

}

TY - JOUR

T1 - Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

AU - Bouchard, Louis S.

AU - Anwar, M. Sabieh

AU - Liu, Gang L.

AU - Hann, Byron

AU - Xie, Z. Harry

AU - Gray, Joe

AU - Wang, Xueding

AU - Pines, Alexander

AU - Chen, Fanqing Frank

PY - 2009/3/17

Y1 - 2009/3/17

N2 - Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

AB - Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.

KW - Dual-modality imaging

KW - Ferromagnetic nanoparticle molecular imaging

KW - MRI contrast

KW - Photoacoustic tomography

UR - http://www.scopus.com/inward/record.url?scp=63149175819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63149175819&partnerID=8YFLogxK

U2 - 10.1073/pnas.0813019106

DO - 10.1073/pnas.0813019106

M3 - Article

C2 - 19251659

AN - SCOPUS:63149175819

VL - 106

SP - 4085

EP - 4089

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 11

ER -