Physiological mechanisms integrating metabolism and reproduction

Stephanie Krasnow, Robert A. Steiner

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

This chapter provides an overview of the physiological mechanisms integrating metabolism and reproduction. The reproductive system of some mammals is more sensitive than others to reductions in energy availability. Of the various factors that dictate an animal's sensitivity to energetic challenges, three are significant-sex, body size, and domestication. The reproductive function is influenced by short-term alterations in metabolic status. The rapidity with which the hypothalamic-pituitary-gonadal (HPG) axis responds to an improved metabolic state is illustrated by multiple observations that pulsatile luteinizing hormone (LH) secretion commences or resumes within minutes to hours after food-restricted prepubertal or adult animals are given unlimited access to food. In addition to the metabolic factors, a variety of other hormones has been implicated in relaying metabolic cues to the neuroendocrine reproductive axis, including growth hormone, insulin-like growth factor I, and glucocorticoids. Based on their anatomical distribution pattern, gonadotropin-releasing hormone (GnRH) neurons appear to be ideally situated to directly detect metabolic fuels and hormones that enter the brain from the systemic circulation.

Original languageEnglish (US)
Title of host publicationKnobil and Neill's Physiology of Reproduction
PublisherElsevier Inc.
Pages2553-2625
Number of pages73
ISBN (Print)9780125154000
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Metabolism
Reproduction
Animals
Hormones
Food
Mammals
Body Size
Luteinizing Hormone
Insulin-Like Growth Factor I
Gonadotropin-Releasing Hormone
Glucocorticoids
Growth Hormone
Neurons
Cues
Brain
Availability
Domestication

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Krasnow, S., & Steiner, R. A. (2006). Physiological mechanisms integrating metabolism and reproduction. In Knobil and Neill's Physiology of Reproduction (pp. 2553-2625). Elsevier Inc.. https://doi.org/10.1016/B978-012515400-0/50052-X

Physiological mechanisms integrating metabolism and reproduction. / Krasnow, Stephanie; Steiner, Robert A.

Knobil and Neill's Physiology of Reproduction. Elsevier Inc., 2006. p. 2553-2625.

Research output: Chapter in Book/Report/Conference proceedingChapter

Krasnow, S & Steiner, RA 2006, Physiological mechanisms integrating metabolism and reproduction. in Knobil and Neill's Physiology of Reproduction. Elsevier Inc., pp. 2553-2625. https://doi.org/10.1016/B978-012515400-0/50052-X
Krasnow S, Steiner RA. Physiological mechanisms integrating metabolism and reproduction. In Knobil and Neill's Physiology of Reproduction. Elsevier Inc. 2006. p. 2553-2625 https://doi.org/10.1016/B978-012515400-0/50052-X
Krasnow, Stephanie ; Steiner, Robert A. / Physiological mechanisms integrating metabolism and reproduction. Knobil and Neill's Physiology of Reproduction. Elsevier Inc., 2006. pp. 2553-2625
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