Physical characteristics and gas composition of nasal air affect nasal nitric oxide release

George Giraud, Bijan Nejadnik, Brent Kimberly, William E. Holden

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    We studied modulation of release of nitric oxide (NO) into nasal passages by physical characteristics (airflow, temperature, humidity) or gases (oxygen, carbon dioxide) in nasal air of humans. Each characteristic or gas in nasal air was changed during voluntary soft palate elevation (to isolate nasal passages). Increasing airflow through the nose caused incremental increases in NO release from 211±23 nl/(min m-2) at 1 L/min to 312±40 nl/(min m-2) at 22 L/min (P2) rapidly and reversibly decreased NO release (200±40 nl/(min m-2) at 21% O2 versus 99±17 nl/(min m-2) at 0% O2 for 3 min, (P

    Original languageEnglish (US)
    Pages (from-to)285-296
    Number of pages12
    JournalRespiration Physiology
    Volume114
    Issue number3
    DOIs
    StatePublished - Dec 1998

    Fingerprint

    Nose
    Nitric Oxide
    Gases
    Air
    Soft Palate
    Humidity
    Carbon Dioxide
    Oxygen
    Temperature

    Keywords

    • Mammals, humans
    • Mediators, NO
    • NO, release, modulation by physical factors and gases
    • Upper airways, modulation of NO release

    ASJC Scopus subject areas

    • Physiology
    • Pulmonary and Respiratory Medicine

    Cite this

    Physical characteristics and gas composition of nasal air affect nasal nitric oxide release. / Giraud, George; Nejadnik, Bijan; Kimberly, Brent; Holden, William E.

    In: Respiration Physiology, Vol. 114, No. 3, 12.1998, p. 285-296.

    Research output: Contribution to journalArticle

    Giraud, George ; Nejadnik, Bijan ; Kimberly, Brent ; Holden, William E. / Physical characteristics and gas composition of nasal air affect nasal nitric oxide release. In: Respiration Physiology. 1998 ; Vol. 114, No. 3. pp. 285-296.
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