Physical and Psychological Symptom Biomechanics in Moderate to Advanced Heart Failure

Quin Denfeld, James Mudd, Jill Gelow, Christopher Chien, Shirin O. Hiatt, Christopher Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: There is a common dissociation between objective measures and patient symptomatology in heart failure (HF). Objective: The aim of this study was to explore the relationship between cardiac biomechanics and physical and psychological symptoms in adults with moderate to advanced HF. Methods: We performed a secondary analysis of data from 2 studies of symptoms among adults with HF. Stepwise regression modeling was performed to examine the influence of cardiac biomechanics (left ventricular internal diastolic diameter, right atrial pressure [RAP], and cardiac index) on symptoms. Results: The average age of the sample (n = 273) was 57 ± 16 years, 61% were men, and 61% had class III or IV HF. Left ventricular internal diastolic diameter (β = 4.22 ± 1.63, P = .011), RAP (β = 0.71 ± 0.28, P = .013), and cardiac index (β = 7.11 ± 3.19, P = .028) were significantly associated with physical symptoms. Left ventricular internal diastolic diameter (β = 0.10 ± 0.05, P = .038) and RAP (β = 0.03 ± 0.01, P = .039) were significantly associated with anxiety. There were no significant biomechanical determinants of depression. Conclusion: Cardiac biomechanics were related to physical symptoms and anxiety, providing preliminary evidence of the biological underpinnings of symptomatology among adults with HF.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalJournal of Cardiovascular Nursing
Volume30
Issue number4
DOIs
StatePublished - Jul 25 2015

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Biomechanical Phenomena
Heart Failure
Atrial Pressure
Psychology
Anxiety
Depression

Keywords

  • biomechanics
  • heart failure
  • hemodynamics
  • symptoms

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Cardiology and Cardiovascular Medicine

Cite this

Physical and Psychological Symptom Biomechanics in Moderate to Advanced Heart Failure. / Denfeld, Quin; Mudd, James; Gelow, Jill; Chien, Christopher; Hiatt, Shirin O.; Lee, Christopher.

In: Journal of Cardiovascular Nursing, Vol. 30, No. 4, 25.07.2015, p. 346-350.

Research output: Contribution to journalArticle

Denfeld, Quin ; Mudd, James ; Gelow, Jill ; Chien, Christopher ; Hiatt, Shirin O. ; Lee, Christopher. / Physical and Psychological Symptom Biomechanics in Moderate to Advanced Heart Failure. In: Journal of Cardiovascular Nursing. 2015 ; Vol. 30, No. 4. pp. 346-350.
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