Physical and Psychological Symptom Biomechanics in Moderate to Advanced Heart Failure

Quin E. Denfeld, James O. Mudd, Jill M. Gelow, Christopher Chien, Shirin O. Hiatt, Christopher S. Lee

Research output: Contribution to journalArticle

6 Scopus citations


Background: There is a common dissociation between objective measures and patient symptomatology in heart failure (HF). Objective: The aim of this study was to explore the relationship between cardiac biomechanics and physical and psychological symptoms in adults with moderate to advanced HF. Methods: We performed a secondary analysis of data from 2 studies of symptoms among adults with HF. Stepwise regression modeling was performed to examine the influence of cardiac biomechanics (left ventricular internal diastolic diameter, right atrial pressure [RAP], and cardiac index) on symptoms. Results: The average age of the sample (n = 273) was 57 ± 16 years, 61% were men, and 61% had class III or IV HF. Left ventricular internal diastolic diameter (β = 4.22 ± 1.63, P = .011), RAP (β = 0.71 ± 0.28, P = .013), and cardiac index (β = 7.11 ± 3.19, P = .028) were significantly associated with physical symptoms. Left ventricular internal diastolic diameter (β = 0.10 ± 0.05, P = .038) and RAP (β = 0.03 ± 0.01, P = .039) were significantly associated with anxiety. There were no significant biomechanical determinants of depression. Conclusion: Cardiac biomechanics were related to physical symptoms and anxiety, providing preliminary evidence of the biological underpinnings of symptomatology among adults with HF.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalJournal of Cardiovascular Nursing
Issue number4
StatePublished - Jul 25 2015



  • biomechanics
  • heart failure
  • hemodynamics
  • symptoms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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