Physical and photochemical properties of ocular melanin

R. D. Glickman, J. M. Gallas, Steven Jacques, B. A. Rockwell, D. K. Sardar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Recent advances in the current state of knowledge about the properties of physiological and synthetic melanin are reviewed in the context of that pigment's optical properties, the physical structure that confers some of its unusual properties, its supportive role in the visual process (by absorbing excess light and reducing intraocular light scatter), its role in some (but not all) laser interactions with ocular tissue, its protective properties (by absorbing potentially phototoxic short-wavelength visible light), and its photoinducible free radical properties. The ability of melanin to form a long-lived radical during visible light irradiation may serve as a protective mechanism against light damage by transforming optical energy into chemical potential energy that can be dissipated in a chain of coupled redox reactions. If a cellular event such as antioxidant depletion occurs that disrupts this chain, however, the melanin radical may promote photo-oxidative damage in ocular tissue. Thus melanin may play two opposing roles in the eye: one protective and the other potentially damaging.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin
Pages112-126
Number of pages15
Volume4241
DOIs
StatePublished - 2001
EventSaratov Fall Meeting 2000 Optical Technologies in Biophysics and Medicine II - Saratov, Russian Federation
Duration: Oct 3 2000Oct 6 2000

Other

OtherSaratov Fall Meeting 2000 Optical Technologies in Biophysics and Medicine II
CountryRussian Federation
CitySaratov
Period10/3/0010/6/00

Fingerprint

Melanin
melanin
physical properties
Tissue
damage
chemical energy
Redox reactions
Chemical potential
antioxidants
Potential energy
pigments
Antioxidants
Free radicals
Pigments
free radicals
depletion
Optical properties
potential energy
Irradiation
optical properties

Keywords

  • Damage
  • Density
  • Laser
  • Melanin
  • Optical properties
  • Photochemistry
  • Retina
  • RPE
  • Structure
  • X-ray scattering

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Glickman, R. D., Gallas, J. M., Jacques, S., Rockwell, B. A., & Sardar, D. K. (2001). Physical and photochemical properties of ocular melanin. In V. V. Tuchin (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4241, pp. 112-126) https://doi.org/10.1117/12.431511

Physical and photochemical properties of ocular melanin. / Glickman, R. D.; Gallas, J. M.; Jacques, Steven; Rockwell, B. A.; Sardar, D. K.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin. Vol. 4241 2001. p. 112-126.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Glickman, RD, Gallas, JM, Jacques, S, Rockwell, BA & Sardar, DK 2001, Physical and photochemical properties of ocular melanin. in VV Tuchin (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4241, pp. 112-126, Saratov Fall Meeting 2000 Optical Technologies in Biophysics and Medicine II, Saratov, Russian Federation, 10/3/00. https://doi.org/10.1117/12.431511
Glickman RD, Gallas JM, Jacques S, Rockwell BA, Sardar DK. Physical and photochemical properties of ocular melanin. In Tuchin VV, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4241. 2001. p. 112-126 https://doi.org/10.1117/12.431511
Glickman, R. D. ; Gallas, J. M. ; Jacques, Steven ; Rockwell, B. A. ; Sardar, D. K. / Physical and photochemical properties of ocular melanin. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin. Vol. 4241 2001. pp. 112-126
@inproceedings{eaef368cbed840b4933ebdd602396f0e,
title = "Physical and photochemical properties of ocular melanin",
abstract = "Recent advances in the current state of knowledge about the properties of physiological and synthetic melanin are reviewed in the context of that pigment's optical properties, the physical structure that confers some of its unusual properties, its supportive role in the visual process (by absorbing excess light and reducing intraocular light scatter), its role in some (but not all) laser interactions with ocular tissue, its protective properties (by absorbing potentially phototoxic short-wavelength visible light), and its photoinducible free radical properties. The ability of melanin to form a long-lived radical during visible light irradiation may serve as a protective mechanism against light damage by transforming optical energy into chemical potential energy that can be dissipated in a chain of coupled redox reactions. If a cellular event such as antioxidant depletion occurs that disrupts this chain, however, the melanin radical may promote photo-oxidative damage in ocular tissue. Thus melanin may play two opposing roles in the eye: one protective and the other potentially damaging.",
keywords = "Damage, Density, Laser, Melanin, Optical properties, Photochemistry, Retina, RPE, Structure, X-ray scattering",
author = "Glickman, {R. D.} and Gallas, {J. M.} and Steven Jacques and Rockwell, {B. A.} and Sardar, {D. K.}",
year = "2001",
doi = "10.1117/12.431511",
language = "English (US)",
volume = "4241",
pages = "112--126",
editor = "V.V. Tuchin",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Physical and photochemical properties of ocular melanin

AU - Glickman, R. D.

AU - Gallas, J. M.

AU - Jacques, Steven

AU - Rockwell, B. A.

AU - Sardar, D. K.

PY - 2001

Y1 - 2001

N2 - Recent advances in the current state of knowledge about the properties of physiological and synthetic melanin are reviewed in the context of that pigment's optical properties, the physical structure that confers some of its unusual properties, its supportive role in the visual process (by absorbing excess light and reducing intraocular light scatter), its role in some (but not all) laser interactions with ocular tissue, its protective properties (by absorbing potentially phototoxic short-wavelength visible light), and its photoinducible free radical properties. The ability of melanin to form a long-lived radical during visible light irradiation may serve as a protective mechanism against light damage by transforming optical energy into chemical potential energy that can be dissipated in a chain of coupled redox reactions. If a cellular event such as antioxidant depletion occurs that disrupts this chain, however, the melanin radical may promote photo-oxidative damage in ocular tissue. Thus melanin may play two opposing roles in the eye: one protective and the other potentially damaging.

AB - Recent advances in the current state of knowledge about the properties of physiological and synthetic melanin are reviewed in the context of that pigment's optical properties, the physical structure that confers some of its unusual properties, its supportive role in the visual process (by absorbing excess light and reducing intraocular light scatter), its role in some (but not all) laser interactions with ocular tissue, its protective properties (by absorbing potentially phototoxic short-wavelength visible light), and its photoinducible free radical properties. The ability of melanin to form a long-lived radical during visible light irradiation may serve as a protective mechanism against light damage by transforming optical energy into chemical potential energy that can be dissipated in a chain of coupled redox reactions. If a cellular event such as antioxidant depletion occurs that disrupts this chain, however, the melanin radical may promote photo-oxidative damage in ocular tissue. Thus melanin may play two opposing roles in the eye: one protective and the other potentially damaging.

KW - Damage

KW - Density

KW - Laser

KW - Melanin

KW - Optical properties

KW - Photochemistry

KW - Retina

KW - RPE

KW - Structure

KW - X-ray scattering

UR - http://www.scopus.com/inward/record.url?scp=0034862486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034862486&partnerID=8YFLogxK

U2 - 10.1117/12.431511

DO - 10.1117/12.431511

M3 - Conference contribution

AN - SCOPUS:0034862486

VL - 4241

SP - 112

EP - 126

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Tuchin, V.V.

ER -