Physical activity and the risk of dementia in oldest old

Aleksandra Sumic, Yvonne L. Michael, Nichole E. Carlson, Diane Howieson, Jeffrey Kaye

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objective: This study evaluated the protective role of physical activity (PA) against cognitive impairment (CI) in the oldest old (age ≥ 85). Method: Prospective data on 66 optimally healthy, oldest old adults (mean age 88.5) were analyzed using survival analysis. Results: In all, 12 men and 11 women reported exercising > 4 hours per week, and 38 participants developed CI (mean onset age 93; mean follow-up 4.7 years). The effect of exercise was modified by gender. In more active women (> 4 hours/week), the risk of CI was reduced by 88% (95% confidence interval 0.03, 0.41) compared to those less active. Less active women had 2 times the incidence rate of CI compared to less active men and almost 5 times the rate compared to active women. Discussion: This study demonstrates the beneficial effects of exercise on healthy brain aging even in the oldest old and emphasizes the importance of increasing PA in older women.

Original languageEnglish (US)
Pages (from-to)242-259
Number of pages18
JournalJournal of Aging and Health
Volume19
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

dementia
Dementia
Exercise
Survival Analysis
old age
Age of Onset
brain
incidence
confidence
Confidence Intervals
Cognitive Dysfunction
Incidence
gender
Brain

Keywords

  • Cognitive impairment
  • Dementia
  • Exercise
  • Oldest old
  • Physical activity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Aging
  • Health(social science)
  • Health Professions(all)

Cite this

Physical activity and the risk of dementia in oldest old. / Sumic, Aleksandra; Michael, Yvonne L.; Carlson, Nichole E.; Howieson, Diane; Kaye, Jeffrey.

In: Journal of Aging and Health, Vol. 19, No. 2, 04.2007, p. 242-259.

Research output: Contribution to journalArticle

Sumic, A, Michael, YL, Carlson, NE, Howieson, D & Kaye, J 2007, 'Physical activity and the risk of dementia in oldest old', Journal of Aging and Health, vol. 19, no. 2, pp. 242-259. https://doi.org/10.1177/0898264307299299
Sumic, Aleksandra ; Michael, Yvonne L. ; Carlson, Nichole E. ; Howieson, Diane ; Kaye, Jeffrey. / Physical activity and the risk of dementia in oldest old. In: Journal of Aging and Health. 2007 ; Vol. 19, No. 2. pp. 242-259.
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