Abstract
The mocha mouse is a spontaneous mutant carrying a defective adaptor-like protein complex AP-3δ subunit. We examined retinal function and histology of the mocha mutant. We found that not only mocha homozygotes but also other littermates in the inbred strain are blind due to severe defects in both rod and cone photoreceptors on electroretinogram recordings. The functional deficit was caused by rapid, early postnatal photoreceptor degeneration. Genotyping confirmed the presence of a viral insertion of rd1 gene in the mocha strain. We conclude that rd1 allele contamination is primarily responsible for photoreceptor degeneration, and caution against behavioral tests with visual cues in the present stocks.
Original language | English (US) |
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Pages (from-to) | 859-865 |
Number of pages | 7 |
Journal | Vision Research |
Volume | 43 |
Issue number | 8 |
DOIs | |
State | Published - Apr 2003 |
Externally published | Yes |
Keywords
- Electroretinograms
- Grizzled
- Mocha
- Mutant mouse
- Photoreceptor degeneration
- rd1 gene
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems