Photoreceptor cell tumors in transgenic mice

K. A. Howes, J. G H Lasudry, Daniel Albert, J. J. Windle

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Purpose. To produce transgenic mice that express the SV40 T-antigen oncogene specifically in photoreceptor cells, giving rise to retinoblastoma tumors of photoreceptor cell origin; to characterize the mice with regard to transgene expression and pathology and to characterize the resulting tumors histologically. Methods. Transgenic mice were generated that express T- antigen under the control of the murine interstitial retinol binding protein promoter. Results. All mice produced developed either ocular or intracranial tumors, or both, at an early age. One line of mice was generated, and all mice of this line develop both retinal photoreceptor cell and pineal tumors by as early as 2 weeks of age. Cell lines have been established from both tumor types. Conclusions. These mice represent an animal model system for human trilateral retinoblastoma, in which retinoblastomas are accompanied by pineal tumors.

Original languageEnglish (US)
Pages (from-to)342-351
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume35
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Photoreceptor Cells
Transgenic Mice
Retinoblastoma
Pinealoma
Neoplasms
Polyomavirus Transforming Antigens
Vertebrate Photoreceptor Cells
Viral Tumor Antigens
Transgenes
Oncogenes
Animal Models
Pathology
Cell Line

Keywords

  • interstitial retinol binding protein
  • pineal tumor
  • retinoblastoma
  • transgenic mice

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Howes, K. A., Lasudry, J. G. H., Albert, D., & Windle, J. J. (1994). Photoreceptor cell tumors in transgenic mice. Investigative Ophthalmology and Visual Science, 35(2), 342-351.

Photoreceptor cell tumors in transgenic mice. / Howes, K. A.; Lasudry, J. G H; Albert, Daniel; Windle, J. J.

In: Investigative Ophthalmology and Visual Science, Vol. 35, No. 2, 01.01.1994, p. 342-351.

Research output: Contribution to journalArticle

Howes, KA, Lasudry, JGH, Albert, D & Windle, JJ 1994, 'Photoreceptor cell tumors in transgenic mice', Investigative Ophthalmology and Visual Science, vol. 35, no. 2, pp. 342-351.
Howes, K. A. ; Lasudry, J. G H ; Albert, Daniel ; Windle, J. J. / Photoreceptor cell tumors in transgenic mice. In: Investigative Ophthalmology and Visual Science. 1994 ; Vol. 35, No. 2. pp. 342-351.
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