TY - JOUR
T1 - Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma
T2 - Results of two randomized studies
AU - Foley, Peter
AU - Freeman, Michael
AU - Menter, Alan
AU - Siller, Gregory
AU - El-Azhary, Rokea A.
AU - Gebauer, Kurt
AU - Lowe, Nicholas J.
AU - Jarratt, Michael T.
AU - Murrell, Dedee F.
AU - Rich, Phoebe
AU - Pariser, David M.
AU - Oseroff, Allan R.
AU - Barnetson, Ross
AU - Anderson, Christopher
AU - Kossard, Steven
AU - Gibson, Lawrence E.
AU - Tope, Whitney D.
PY - 2009/11
Y1 - 2009/11
N2 - Background: Data suggest that photodynamic therapy using topical methyl aminolevulinate (MAL PDT) may be a noninvasive alternative to excisional surgery for nodular basal cell carcinoma (BCC). In the studies described here, we investigated the histologic response, tolerability, and cosmetic outcome with MAL PDT for primary nodular BCC (≤ 5 mm in depth). Methods: Two multicenter, randomized, double-blind studies with similar design and procedures were conducted. After surface debridement and minor tumor debulking, MAL cream 160 mg/g (66 patients with 75 lesions) or placebo cream (65 patients with 75 lesions) was applied for 3 h, followed by illumination with broad-spectrum red light (75 J/cm2, 570-670 nm). This was repeated 7 days later. Lesions with a partial response (≥ 50% reduction in greatest diameter) at 3 months were re-treated (21%). Treatment sites were excised at 3 months (clinical nonresponders) or 6 months (clinical responders) after the last treatment. Results: Histologically verified lesion complete response rates were higher with MAL PDT than with placebo [73% (55/75) vs. 27% (20/75)]. Treatment was most effective for facial lesions (89% complete response). Cosmetic outcome was good or excellent in 98% of evaluable, completely responding lesions treated with MAL PDT. Conclusion: Although longer follow-up studies are required, these promising data indicate the potential of topical MAL PDT as a noninvasive treatment alternative for nodular BCC.
AB - Background: Data suggest that photodynamic therapy using topical methyl aminolevulinate (MAL PDT) may be a noninvasive alternative to excisional surgery for nodular basal cell carcinoma (BCC). In the studies described here, we investigated the histologic response, tolerability, and cosmetic outcome with MAL PDT for primary nodular BCC (≤ 5 mm in depth). Methods: Two multicenter, randomized, double-blind studies with similar design and procedures were conducted. After surface debridement and minor tumor debulking, MAL cream 160 mg/g (66 patients with 75 lesions) or placebo cream (65 patients with 75 lesions) was applied for 3 h, followed by illumination with broad-spectrum red light (75 J/cm2, 570-670 nm). This was repeated 7 days later. Lesions with a partial response (≥ 50% reduction in greatest diameter) at 3 months were re-treated (21%). Treatment sites were excised at 3 months (clinical nonresponders) or 6 months (clinical responders) after the last treatment. Results: Histologically verified lesion complete response rates were higher with MAL PDT than with placebo [73% (55/75) vs. 27% (20/75)]. Treatment was most effective for facial lesions (89% complete response). Cosmetic outcome was good or excellent in 98% of evaluable, completely responding lesions treated with MAL PDT. Conclusion: Although longer follow-up studies are required, these promising data indicate the potential of topical MAL PDT as a noninvasive treatment alternative for nodular BCC.
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U2 - 10.1111/j.1365-4632.2008.04022.x
DO - 10.1111/j.1365-4632.2008.04022.x
M3 - Article
C2 - 20064185
AN - SCOPUS:70449433090
SN - 0011-9059
VL - 48
SP - 1236
EP - 1245
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 11
ER -