Abstract
To study the vascular effects of a new photosensitizing agent independent of the influence of tumor growth, a cutaneous wound model was used. Six-week-old Harlan-Sprague-Dawley "Fuzzy" rats were surgically wounded in a standard fashion. The animals were then divided into three groups: the first group received chloroaluminum - sulfonated phthalocyanine only, the second group was treated with light only, and a third group was treated with both chloroaluminum-sulfonated phthalocyanine and light. Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine had a direct effect on the neovasculature of a healing wound. The vasodilatation that was seen in the wound neovasculature that occurred 12 hours after the completion of chloroaluminum-sulfonated phthalocyanine—photodynamic therapy may have indicated a therapeutic "window" at which other therapies can be employed to improve clinical efficacy. (Arch Otolaryngol Head Neck Surg. 1990;116:1259-1266)
Original language | English (US) |
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Pages (from-to) | 1259-1266 |
Number of pages | 8 |
Journal | Archives of Otolaryngology--Head and Neck Surgery |
Volume | 116 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1990 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology