Photodynamic Therapy With Chloroaluminum-Sulfonated Phthalocyanine

Scott J. Stern, Sharon Thomsen, Susan Small, Steven Jacques

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To study the vascular effects of a new photosensitizing agent independent of the influence of tumor growth, a cutaneous wound model was used. Six-week-old Harlan-Sprague-Dawley "Fuzzy" rats were surgically wounded in a standard fashion. The animals were then divided into three groups: the first group received chloroaluminum - sulfonated phthalocyanine only, the second group was treated with light only, and a third group was treated with both chloroaluminum-sulfonated phthalocyanine and light. Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine had a direct effect on the neovasculature of a healing wound. The vasodilatation that was seen in the wound neovasculature that occurred 12 hours after the completion of chloroaluminum-sulfonated phthalocyanine—photodynamic therapy may have indicated a therapeutic "window" at which other therapies can be employed to improve clinical efficacy. (Arch Otolaryngol Head Neck Surg. 1990;116:1259-1266)

Original languageEnglish (US)
Pages (from-to)1259-1266
Number of pages8
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume116
Issue number11
DOIs
StatePublished - 1990
Externally publishedYes

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Photochemotherapy
Light
Photosensitizing Agents
Wounds and Injuries
Vasodilation
Wound Healing
Blood Vessels
Sprague Dawley Rats
Therapeutics
Head
Skin
Growth
chloroaluminum phthalocyanine
Neoplasms

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Photodynamic Therapy With Chloroaluminum-Sulfonated Phthalocyanine. / Stern, Scott J.; Thomsen, Sharon; Small, Susan; Jacques, Steven.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 116, No. 11, 1990, p. 1259-1266.

Research output: Contribution to journalArticle

Stern, Scott J. ; Thomsen, Sharon ; Small, Susan ; Jacques, Steven. / Photodynamic Therapy With Chloroaluminum-Sulfonated Phthalocyanine. In: Archives of Otolaryngology - Head and Neck Surgery. 1990 ; Vol. 116, No. 11. pp. 1259-1266.
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