Photodynamic Therapy With Chloroaluminum-Sulfonated Phthalocyanine

Scott J. Stern, Sharon Thomsen, Susan Small, Steven Jacques

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To study the vascular effects of a new photosensitizing agent independent of the influence of tumor growth, a cutaneous wound model was used. Six-week-old Harlan-Sprague-Dawley "Fuzzy" rats were surgically wounded in a standard fashion. The animals were then divided into three groups: the first group received chloroaluminum - sulfonated phthalocyanine only, the second group was treated with light only, and a third group was treated with both chloroaluminum-sulfonated phthalocyanine and light. Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine had a direct effect on the neovasculature of a healing wound. The vasodilatation that was seen in the wound neovasculature that occurred 12 hours after the completion of chloroaluminum-sulfonated phthalocyanine—photodynamic therapy may have indicated a therapeutic "window" at which other therapies can be employed to improve clinical efficacy. (Arch Otolaryngol Head Neck Surg. 1990;116:1259-1266)

Original languageEnglish (US)
Pages (from-to)1259-1266
Number of pages8
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume116
Issue number11
DOIs
StatePublished - Nov 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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