Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate

Matthias Mentel, Vibor Laketa, Devaraj Subramanian, Hartmut Gillandt, Carsten Schultz

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

(Figure Presented) Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection ("uncaging") with a laser flash, in live cells.

Original languageEnglish (US)
Pages (from-to)3811-3814
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number16
DOIs
StatePublished - Apr 11 2011
Externally publishedYes

Fingerprint

Cell membranes
Molecules
Bioactivity
Chemical activation
Derivatives
Lasers
phosphatidylinositol 3,4,5-triphosphate
phosphoinositide-3,4,5-triphosphate

Keywords

  • Caged compounds
  • Kinases
  • Phospholipids
  • Signal transduction

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate. / Mentel, Matthias; Laketa, Vibor; Subramanian, Devaraj; Gillandt, Hartmut; Schultz, Carsten.

In: Angewandte Chemie - International Edition, Vol. 50, No. 16, 11.04.2011, p. 3811-3814.

Research output: Contribution to journalArticle

Mentel, Matthias ; Laketa, Vibor ; Subramanian, Devaraj ; Gillandt, Hartmut ; Schultz, Carsten. / Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 16. pp. 3811-3814.
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