Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate

Matthias Mentel; Vibor Laketa; Devaraj Subramanian; Hartmut Gillandt; Carsten Schultz

doi:10.1002/anie.201007796

Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate

Matthias Mentel, Vibor Laketa, Devaraj Subramanian, Hartmut Gillandt, Carsten Schultz

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

(Figure Presented) Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection ("uncaging") with a laser flash, in live cells.

Original language	English (US)
Pages (from-to)	3811-3814
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	16
DOIs	https://doi.org/10.1002/anie.201007796
State	Published - Apr 11 2011
Externally published	Yes

Keywords

Caged compounds
Kinases
Phospholipids
Signal transduction

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201007796

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abstract = "(Figure Presented) Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection ({"}uncaging{"}) with a laser flash, in live cells.",

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AU - Mentel, Matthias

AU - Laketa, Vibor

AU - Subramanian, Devaraj

AU - Gillandt, Hartmut

AU - Schultz, Carsten

PY - 2011/4/11

Y1 - 2011/4/11

N2 - (Figure Presented) Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection ("uncaging") with a laser flash, in live cells.

AB - (Figure Presented) Unleashed inside cells: The signaling molecule PI(3,4,5)P3 is prepared in a form that allows its cellular uptake and subsequent activation by light (see picture). The rapid eight-step synthetic sequence yields a stable derivative of the signaling molecule with high biological activity after deprotection ("uncaging") with a laser flash, in live cells.

KW - Caged compounds

KW - Kinases

KW - Phospholipids

KW - Signal transduction

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Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate

Abstract

Keywords

ASJC Scopus subject areas

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