Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors

Yu Sun, Dimphna H. Meijer, John A. Alberta, Shwetal Mehta, Michael F. Kane, An Chi Tien, Hui Fu, Magdalena Petryniak, Gregory Potter, Zijing Liu, James F. Powers, I. Sophie Runquist, David H. Rowitch, Charles D. Stiles

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The bHLH transcription factors that regulate early development of the central nervous system can generally be classified as either antineural or proneural. Initial expression of antineural factors prevents cell cycle exit and thereby expands the pool of neural progenitors. Subsequent (and typically transient) expression of proneural factors promotes cell cycle exit, subtype specification, and differentiation. Against this backdrop, the bHLH transcription factor Olig2 in the oligodendrocyte lineage is unorthodox, showing antineural functions in multipotent CNS progenitor cells but also sustained expression and proneural functions in the formation of oligodendrocytes. We show here that the proliferative function of Olig2 is controlled by developmentally regulated phosphorylation of a conserved triple serine motif within the amino-terminal domain. In the phosphorylated state, Olig2 maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary glioma.

Original languageEnglish (US)
Pages (from-to)906-917
Number of pages12
JournalNeuron
Volume69
Issue number5
DOIs
StatePublished - Mar 10 2011
Externally publishedYes

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Basic Helix-Loop-Helix Transcription Factors
Oligodendroglia
Glioma
Cell Cycle
Phosphorylation
Serine
Stem Cells
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sun, Y., Meijer, D. H., Alberta, J. A., Mehta, S., Kane, M. F., Tien, A. C., ... Stiles, C. D. (2011). Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors. Neuron, 69(5), 906-917. https://doi.org/10.1016/j.neuron.2011.02.005

Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors. / Sun, Yu; Meijer, Dimphna H.; Alberta, John A.; Mehta, Shwetal; Kane, Michael F.; Tien, An Chi; Fu, Hui; Petryniak, Magdalena; Potter, Gregory; Liu, Zijing; Powers, James F.; Runquist, I. Sophie; Rowitch, David H.; Stiles, Charles D.

In: Neuron, Vol. 69, No. 5, 10.03.2011, p. 906-917.

Research output: Contribution to journalArticle

Sun, Y, Meijer, DH, Alberta, JA, Mehta, S, Kane, MF, Tien, AC, Fu, H, Petryniak, M, Potter, G, Liu, Z, Powers, JF, Runquist, IS, Rowitch, DH & Stiles, CD 2011, 'Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors', Neuron, vol. 69, no. 5, pp. 906-917. https://doi.org/10.1016/j.neuron.2011.02.005
Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC et al. Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors. Neuron. 2011 Mar 10;69(5):906-917. https://doi.org/10.1016/j.neuron.2011.02.005
Sun, Yu ; Meijer, Dimphna H. ; Alberta, John A. ; Mehta, Shwetal ; Kane, Michael F. ; Tien, An Chi ; Fu, Hui ; Petryniak, Magdalena ; Potter, Gregory ; Liu, Zijing ; Powers, James F. ; Runquist, I. Sophie ; Rowitch, David H. ; Stiles, Charles D. / Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors. In: Neuron. 2011 ; Vol. 69, No. 5. pp. 906-917.
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