Phosphodiesterase inhibition by Ro 20-1724 reduces hyper-IgE synthesis by atopic dermatitis cells in vitro

K. D. Cooper, K. Kang, S. C. Chan, Jon Hanifin

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Peripheral blood mononuclear leukocytes (MNL) from patients with atopic dermatitis spontaneously produce large amounts of IgE in vitro. These cells also show markedly elevated levels of cAMP phosphodiesterase (PDE) which may be responsible for the observed abnormal cAMP responsiveness. Treatment of atopic dermatitis MNL with varying concentrations of the cAMP PDE inhibitor Ro 20-1724 resulted in progressively decreasing amounts of IgE synthesis, statistically significant at the 10-4 M and 10-5 M concentrations. There was a close correlation between PDE inhibition and inhibition of IgE synthesis, r = 0.93, p

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalJournal of Investigative Dermatology
Volume84
Issue number6
StatePublished - 1985

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4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Phosphoric Diester Hydrolases
Atopic Dermatitis
Immunoglobulin E
Mononuclear Leukocytes
Phosphodiesterase Inhibitors
Blood
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Dermatology

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Phosphodiesterase inhibition by Ro 20-1724 reduces hyper-IgE synthesis by atopic dermatitis cells in vitro. / Cooper, K. D.; Kang, K.; Chan, S. C.; Hanifin, Jon.

In: Journal of Investigative Dermatology, Vol. 84, No. 6, 1985, p. 477-482.

Research output: Contribution to journalArticle

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