Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain

R. A. Harris, J. Schmidt, B. A. Hitzemann, Robert Hitzemann

Research output: Contribution to journalArticle

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Phosphatidate, a neuronal phospholipid, stimulated the uptake of calcium by nerve terminals isolated from the striatum of rat brain. This effect was not produced by other phospholipids or glycolipids. Phosphatidate, but not other phospholipids, evoked the release of [3H]dopamine from striatal synaptosomes. The magnitude of both effects was similar to that observed after chemical depolarization of the nerve terminals. These results show that phosphatidate is the only membrane lipid component that acts as a functionally competent ionophore and support the suggestion that phosphatidate may serve as a link between depolarization and neurotransmitter release in the brain.

Original languageEnglish (US)
Pages (from-to)1290-1291
Number of pages2
Issue number4500
Publication statusPublished - 1981
Externally publishedYes


ASJC Scopus subject areas

  • General

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