Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain

R. Adron Harris, J. I M Schmidt, Barbara A. Hitzemann, Robert Hitzemann

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Phosphatidate, a neuronal phospholipid, stimulated the uptake of calcium by nerve terminals isolated from the striatum of rat brain. This effect was not produced by other phospholipids or glycolipids. Phosphatidate, but not other phospholipids, evoked the release of [3H]dopamine from striatal synaptosomes. The magnitude of both effects was similar to that observed after chemical depolarization of the nerve terminals. These results show that phosphatidate is the only membrane lipid component that acts as a functionally competent ionophore and support the suggestion that phosphatidate may serve as a link between depolarization and neurotransmitter release in the brain.

Original languageEnglish (US)
Pages (from-to)1291-1293
Number of pages3
JournalScience
Volume212
Issue number4500
StatePublished - 1981
Externally publishedYes

Fingerprint

Neurotransmitter Agents
Phospholipids
Brain
Corpus Striatum
Synaptosomes
Glycolipids
Ionophores
Membrane Lipids
Dopamine
Calcium

ASJC Scopus subject areas

  • General

Cite this

Adron Harris, R., Schmidt, J. I. M., Hitzemann, B. A., & Hitzemann, R. (1981). Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain. Science, 212(4500), 1291-1293.

Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain. / Adron Harris, R.; Schmidt, J. I M; Hitzemann, Barbara A.; Hitzemann, Robert.

In: Science, Vol. 212, No. 4500, 1981, p. 1291-1293.

Research output: Contribution to journalArticle

Adron Harris, R, Schmidt, JIM, Hitzemann, BA & Hitzemann, R 1981, 'Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain', Science, vol. 212, no. 4500, pp. 1291-1293.
Adron Harris, R. ; Schmidt, J. I M ; Hitzemann, Barbara A. ; Hitzemann, Robert. / Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain. In: Science. 1981 ; Vol. 212, No. 4500. pp. 1291-1293.
@article{aeb13642c815423c88597db905c80799,
title = "Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain",
abstract = "Phosphatidate, a neuronal phospholipid, stimulated the uptake of calcium by nerve terminals isolated from the striatum of rat brain. This effect was not produced by other phospholipids or glycolipids. Phosphatidate, but not other phospholipids, evoked the release of [3H]dopamine from striatal synaptosomes. The magnitude of both effects was similar to that observed after chemical depolarization of the nerve terminals. These results show that phosphatidate is the only membrane lipid component that acts as a functionally competent ionophore and support the suggestion that phosphatidate may serve as a link between depolarization and neurotransmitter release in the brain.",
author = "{Adron Harris}, R. and Schmidt, {J. I M} and Hitzemann, {Barbara A.} and Robert Hitzemann",
year = "1981",
language = "English (US)",
volume = "212",
pages = "1291--1293",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4500",

}

TY - JOUR

T1 - Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain

AU - Adron Harris, R.

AU - Schmidt, J. I M

AU - Hitzemann, Barbara A.

AU - Hitzemann, Robert

PY - 1981

Y1 - 1981

N2 - Phosphatidate, a neuronal phospholipid, stimulated the uptake of calcium by nerve terminals isolated from the striatum of rat brain. This effect was not produced by other phospholipids or glycolipids. Phosphatidate, but not other phospholipids, evoked the release of [3H]dopamine from striatal synaptosomes. The magnitude of both effects was similar to that observed after chemical depolarization of the nerve terminals. These results show that phosphatidate is the only membrane lipid component that acts as a functionally competent ionophore and support the suggestion that phosphatidate may serve as a link between depolarization and neurotransmitter release in the brain.

AB - Phosphatidate, a neuronal phospholipid, stimulated the uptake of calcium by nerve terminals isolated from the striatum of rat brain. This effect was not produced by other phospholipids or glycolipids. Phosphatidate, but not other phospholipids, evoked the release of [3H]dopamine from striatal synaptosomes. The magnitude of both effects was similar to that observed after chemical depolarization of the nerve terminals. These results show that phosphatidate is the only membrane lipid component that acts as a functionally competent ionophore and support the suggestion that phosphatidate may serve as a link between depolarization and neurotransmitter release in the brain.

UR - http://www.scopus.com/inward/record.url?scp=37049179550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049179550&partnerID=8YFLogxK

M3 - Article

VL - 212

SP - 1291

EP - 1293

JO - Science

JF - Science

SN - 0036-8075

IS - 4500

ER -