Pheromone-induced anorexia in male Syrian hamsters

Caurnel Morgan, Henryk Urbanski, Wei Fan, Huda Akil, Roger D. Cone

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Transition from long days (LDs) to short days (SDs) triggers seasonal obesity in Syrian hamsters. We report here that SD-exposed males housed near females exhibit obesity resistance, episodic weight loss, and reduced adiposity. Negative energy balance is achieved by reduced eating, elevated motor activity, and increased caloric efficiency without metabolic compensation. Circulating leptin, insulin, testosterone, corticosterone, and cortisol are normal or reduced in obesity-resistant hamsters. When males are housed in chambers that block physical, visual, and auditory, but not pheromonal, signals from females, resistance to seasonal obesity persists. Moreover, inhalation of extracts from pheromone-releasing flank glands of females suppresses eating and weight gain in SD-exposed males. This novel phenomenon, pheromone-induced anorexia, shows that female pheromones play a critical role in the seasonal energy balance of male hamsters. These findings provide a model to study neural and endocrine mechanisms that underlie eating disorders.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume285
Issue number5 48-5
StatePublished - Nov 2003

Fingerprint

Pheromones
Mesocricetus
Anorexia
Obesity
Energy balance
Cricetinae
Eating
Corticosterone
Leptin
Hydrocortisone
Testosterone
Adiposity
Insulin
Inhalation
Weight Gain
Weight Loss
Motor Activity

Keywords

  • Hypercaloric
  • Hypocaloric
  • Locomotor activity
  • Mesocricetus auratus
  • Oxygen consumption

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Pheromone-induced anorexia in male Syrian hamsters. / Morgan, Caurnel; Urbanski, Henryk; Fan, Wei; Akil, Huda; Cone, Roger D.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 285, No. 5 48-5, 11.2003.

Research output: Contribution to journalArticle

Morgan, Caurnel ; Urbanski, Henryk ; Fan, Wei ; Akil, Huda ; Cone, Roger D. / Pheromone-induced anorexia in male Syrian hamsters. In: American Journal of Physiology - Endocrinology and Metabolism. 2003 ; Vol. 285, No. 5 48-5.
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