Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops)

Lois Colgin, D. J. Schwahn, F. Castillo-Alcala, M. Kiupel, Anne Lewis

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Pheochromocytoma, a rarely reported adrenal gland neoplasm in Old World primates, was diagnosed in 5 rhesus macaques (Macaca mulatta) and 2 African green monkeys (Chlorocebus aethiops) from 3 research institutions. Age and sex were available for 6 primates. Two males and 4 females were affected, ranging in age from 9 to 31 years. All neoplasms were unilateral and, in the cases reporting the affected gland, 4 involved the right adrenal gland and 2 involved the left. Diagnosis was established by characteristic histologic features. Immunohistochemically, neoplastic cells in all cases expressed chromogranin A and met-enkephalin and were negative for melan-A and inhibin. Six of 7 tumors were positive for β-endorphin. Pulmonary metastases were present in 2 rhesus macaques and portal vein invasion in 1 African green monkey. To the authors’ knowledge, this is the first report of malignant pheochromocytoma in Old World primates.

    Original languageEnglish (US)
    Pages (from-to)1259-1263
    Number of pages5
    JournalVeterinary Pathology
    Volume53
    Issue number6
    DOIs
    StatePublished - Nov 1 2016

    Fingerprint

    Cercopithecus aethiops
    Pheochromocytoma
    Macaca mulatta
    Primates
    adrenal glands
    neoplasms
    Adrenal Gland Neoplasms
    MART-1 Antigen
    Endorphins
    endorphins
    Chromogranin A
    inhibin
    Methionine Enkephalin
    Inhibins
    research institutions
    portal vein
    Adrenal Glands
    Portal Vein
    metastasis
    Neoplasms

    Keywords

    • adrenal gland neoplasm
    • African green monkey
    • Chlorocebus aethiops
    • immunohistochemistry
    • Macaca mulatta
    • Old World primate
    • pheochromocytoma
    • rhesus macaque

    ASJC Scopus subject areas

    • veterinary(all)

    Cite this

    Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops). / Colgin, Lois; Schwahn, D. J.; Castillo-Alcala, F.; Kiupel, M.; Lewis, Anne.

    In: Veterinary Pathology, Vol. 53, No. 6, 01.11.2016, p. 1259-1263.

    Research output: Contribution to journalArticle

    Colgin, Lois ; Schwahn, D. J. ; Castillo-Alcala, F. ; Kiupel, M. ; Lewis, Anne. / Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops). In: Veterinary Pathology. 2016 ; Vol. 53, No. 6. pp. 1259-1263.
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