Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops)

L. M.A. Colgin, D. J. Schwahn, F. Castillo-Alcala, M. Kiupel, A. D. Lewis

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    Pheochromocytoma, a rarely reported adrenal gland neoplasm in Old World primates, was diagnosed in 5 rhesus macaques (Macaca mulatta) and 2 African green monkeys (Chlorocebus aethiops) from 3 research institutions. Age and sex were available for 6 primates. Two males and 4 females were affected, ranging in age from 9 to 31 years. All neoplasms were unilateral and, in the cases reporting the affected gland, 4 involved the right adrenal gland and 2 involved the left. Diagnosis was established by characteristic histologic features. Immunohistochemically, neoplastic cells in all cases expressed chromogranin A and met-enkephalin and were negative for melan-A and inhibin. Six of 7 tumors were positive for β-endorphin. Pulmonary metastases were present in 2 rhesus macaques and portal vein invasion in 1 African green monkey. To the authors’ knowledge, this is the first report of malignant pheochromocytoma in Old World primates.

    Original languageEnglish (US)
    Pages (from-to)1259-1263
    Number of pages5
    JournalVeterinary pathology
    Volume53
    Issue number6
    DOIs
    StatePublished - Nov 1 2016

    Keywords

    • African green monkey
    • Chlorocebus aethiops
    • Macaca mulatta
    • Old World primate
    • adrenal gland neoplasm
    • immunohistochemistry
    • pheochromocytoma
    • rhesus macaque

    ASJC Scopus subject areas

    • veterinary(all)

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