Phenotypic Variation Including Retinitis Pigmentosa, Pattern Dystrophy, and Fundus Flavimaculatus in a Single Family With a Deletion of Codon 153 or 154 of the Peripherin/RDS Gene

Richard Weleber, Ronald E. Carr, William H. Murphey, Val C. Sheffield, Edwin M. Stone

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Abstract

Mutations of the peripherin/RDS gene have been reported in autosomal dominant retinitis pigmentosa, pattern macular dystrophy, and retinitis punctata albescens. We report herein the occurrence of three separate phenotypes within a single family with a novel 3—base pair deletion of codon 153 or 154 of the peripherin/RDS gene. Case reports with clinical features, fluorescein angiography, kinetic perimetry, electrophysiological studies, and molecular genetics. University medical centers. A 75-year-old woman, her two daughters (aged 44 and 50 years), and her 49-year-old son were screened for peripherin/RDS mutations because of the presence of multiple phenotypes within the same family. The mother presented at age 63 years with a profoundly abnormal electroretinogram (ERG) and adult-onset retinitis pigmentosa that progressed dramatically over 12 years, with marked loss of peripheral visual field. One daughter developed pattern macular dystrophy at age 31 years. At age 44 years, her ERG was moderately abnormal but her clinical disease was limited to the macula. Another daughter presented at age 42 years with macular degeneration and over 10 years developed the clinical picture of fundus flavimaculatus. Her peripheral visual field was preserved but her ERG was moderately abnormal. The son had onset of macular degeneration at age 44 years. Pericentral scotomas were present and the ERG was markedly abnormal. Fluorescein angiography revealed punctate pigment epithelial transmission defects. A 3—base pair deletion of codon 153 or 154 of the peripherin/RDS gene can produce clinically disparate phenotypes even within the same family.

Original languageEnglish (US)
Pages (from-to)1531-1542
Number of pages12
JournalArchives of Ophthalmology
Volume111
Issue number11
DOIs
StatePublished - 1993

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Peripherins
Retinitis Pigmentosa
Nuclear Family
Codon
Macular Degeneration
Fluorescein Angiography
Genes
Visual Fields
Phenotype
Scotoma
Mutation
Visual Field Tests
Molecular Biology
Mothers
Stargardt disease 1

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Phenotypic Variation Including Retinitis Pigmentosa, Pattern Dystrophy, and Fundus Flavimaculatus in a Single Family With a Deletion of Codon 153 or 154 of the Peripherin/RDS Gene. / Weleber, Richard; Carr, Ronald E.; Murphey, William H.; Sheffield, Val C.; Stone, Edwin M.

In: Archives of Ophthalmology, Vol. 111, No. 11, 1993, p. 1531-1542.

Research output: Contribution to journalArticle

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