TY - JOUR
T1 - Phenotype ontologies
T2 - the bridge between genomics and evolution
AU - Mabee, Paula M.
AU - Ashburner, Michael
AU - Cronk, Quentin
AU - Gkoutos, Georgios V.
AU - Haendel, Melissa
AU - Segerdell, Erik
AU - Mungall, Chris
AU - Westerfield, Monte
N1 - Funding Information:
We thank the NSF National Evolutionary Synthesis Center (EF-0423641), NSF 0431290, NIH HG002659 and HG004028 for support. G.V.G. is supported by the National Center for Biomedical Ontology (NIH: 1-U54-HG004028-01). We thank Adam Amsterdam and Nancy Hopkins for use of the image in Figure 2 .
PY - 2007/7
Y1 - 2007/7
N2 - Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways.
AB - Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways.
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U2 - 10.1016/j.tree.2007.03.013
DO - 10.1016/j.tree.2007.03.013
M3 - Article
C2 - 17416439
AN - SCOPUS:34250625734
SN - 0169-5347
VL - 22
SP - 345
EP - 350
JO - Trends in Ecology and Evolution
JF - Trends in Ecology and Evolution
IS - 7
ER -