Phase-resolved reflectance spectroscopy on layered turbid media

Andreas H. Hielscher, Hanli Liu, Britton Chance, Frank K. Tittel, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

In this study, we investigate the influence of layered tissue structures on the phase-resolved reflectance. As a particular example, we consider the affect of the skin, skull, and meninges on noninvasive blood oxygenation determination of the brain. In this case, it's important to know how accurate one can measure the absorption coefficient of the brain through the enclosing layers of different tissues. Experiments were performed on layered gelatin tissue phantoms and the results compared to diffusion theory. It is shown that when a high absorbing medium is placed on top of a low absorbing medium, the absorption coefficient of the lower layer is accessible. In the inverse case, where a low absorbing medium is placed on top of a high absorbing medium, the absorption coefficient of the underlying medium can only be determined if the differences in the absorption coefficient are small, or the top layer is very thin. Investigations on almost absorption and scattering free layers, like the cerebral fluid filled arachnoid, reveal that the determination of the absorption coefficient is barely affected by these kinds of structures.

Original languageEnglish (US)
Title of host publicationOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media
Subtitle of host publicationTheory, Human Studies, and Instrumentation
EditorsBritton Chance, Robert R. Alfano
PublisherSPIE
Pages248-256
Number of pages9
Volume2389
ISBN (Electronic)9780819417367
DOIs
StatePublished - May 30 1995
Externally publishedYes
EventOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation - San Jose, United States
Duration: Feb 1 1995Feb 28 1995

Other

OtherOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
CountryUnited States
CitySan Jose
Period2/1/952/28/95

Fingerprint

Layered Media
Absorption Coefficient
Reflectance
Spectroscopy
absorptivity
Absorbing
Tissue
reflectance
Brain
spectroscopy
Oxygenation
brain
Gelatin
Skin
Blood
skull
diffusion theory
Scattering
oxygenation
gelatins

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Hielscher, A. H., Liu, H., Chance, B., Tittel, F. K., & Jacques, S. (1995). Phase-resolved reflectance spectroscopy on layered turbid media. In B. Chance, & R. R. Alfano (Eds.), Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation (Vol. 2389, pp. 248-256). SPIE. https://doi.org/10.1117/12.209974

Phase-resolved reflectance spectroscopy on layered turbid media. / Hielscher, Andreas H.; Liu, Hanli; Chance, Britton; Tittel, Frank K.; Jacques, Steven.

Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. ed. / Britton Chance; Robert R. Alfano. Vol. 2389 SPIE, 1995. p. 248-256.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hielscher, AH, Liu, H, Chance, B, Tittel, FK & Jacques, S 1995, Phase-resolved reflectance spectroscopy on layered turbid media. in B Chance & RR Alfano (eds), Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. vol. 2389, SPIE, pp. 248-256, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, San Jose, United States, 2/1/95. https://doi.org/10.1117/12.209974
Hielscher AH, Liu H, Chance B, Tittel FK, Jacques S. Phase-resolved reflectance spectroscopy on layered turbid media. In Chance B, Alfano RR, editors, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. Vol. 2389. SPIE. 1995. p. 248-256 https://doi.org/10.1117/12.209974
Hielscher, Andreas H. ; Liu, Hanli ; Chance, Britton ; Tittel, Frank K. ; Jacques, Steven. / Phase-resolved reflectance spectroscopy on layered turbid media. Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. editor / Britton Chance ; Robert R. Alfano. Vol. 2389 SPIE, 1995. pp. 248-256
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