TY - JOUR
T1 - Phase 2 safety trial targeting amyloid β production with a γ-secretase inhibitor in Alzheimer disease
AU - Fleisher, Adam S.
AU - Raman, Rema
AU - Siemers, Eric R.
AU - Becerra, Lida
AU - Clark, Christopher M.
AU - Dean, Robert A.
AU - Farlow, Martin R.
AU - Galvin, James E.
AU - Peskind, Elaine R.
AU - Quinn, Joseph F.
AU - Sherzai, Abdullah
AU - Sowell, B. Brooke
AU - Aisen, Paul S.
AU - Thal, Leon J.
PY - 2008/8
Y1 - 2008/8
N2 - Objective: To evaluate the safety, tolerability, and amyloid β (Aβ) response to the γ-secretase inhibitor LY450139 in Alzheimer disease. Design: Multicenter, randomized, double-blind, dose-escalation, placebo-controlled trial. Setting: Community-based clinical research centers. Patients: Fifty-one individuals with mild to moderate Alzheimer disease were randomized to receive placebo (n=15) or LY450139 (100 mg [n=22] or 140 mg [n=14]), with 43 completing the treatment phase. Intervention: The LY450139 groups received 60 mg/d for 2 weeks, then 100 mg/d for 6 weeks, and then either 100 or 140 mg/d for 6 additional weeks. Main Outcome Measures: Primary outcome measures were adverse events, plasma and cerebrospinal fluid Aβ levels, vital signs, electrocardiographic data, and laboratory safety test results. Secondary outcome measures included the Alzheimer's Disease Assessment Scale cognitive subscale and the Alzheimer's Disease Cooperative Study Activities of Daily Living Scale. Results: Group differences were seen in skin and subcutaneous tissue concerns (P=.05), including 3 possible drug rashes and 3 reports of hair color change in the treatment groups. There were 3 adverse event-related discontinuations, including 1 transient bowel obstruction. The plasma Aβ40 concentration was reduced by 58.2% for the 100-mg group and 64.6% for the 140-mg group (P<.001). No significant reduction was seen in cerebrospinal fluid Aβ levels. No group differences were seen in cognitive or functional measures. Conclusions: LY450139 was generally well tolerated at doses of up to 140 mg/d for 14 weeks, with several findings indicating the need for close clinical monitoring in future studies. Decreases in plasma Aβ concentrations were consistent with inhibition of γ-secretase. Trial Registration: clinicaltrials.gov Identifier: NCT00244322
AB - Objective: To evaluate the safety, tolerability, and amyloid β (Aβ) response to the γ-secretase inhibitor LY450139 in Alzheimer disease. Design: Multicenter, randomized, double-blind, dose-escalation, placebo-controlled trial. Setting: Community-based clinical research centers. Patients: Fifty-one individuals with mild to moderate Alzheimer disease were randomized to receive placebo (n=15) or LY450139 (100 mg [n=22] or 140 mg [n=14]), with 43 completing the treatment phase. Intervention: The LY450139 groups received 60 mg/d for 2 weeks, then 100 mg/d for 6 weeks, and then either 100 or 140 mg/d for 6 additional weeks. Main Outcome Measures: Primary outcome measures were adverse events, plasma and cerebrospinal fluid Aβ levels, vital signs, electrocardiographic data, and laboratory safety test results. Secondary outcome measures included the Alzheimer's Disease Assessment Scale cognitive subscale and the Alzheimer's Disease Cooperative Study Activities of Daily Living Scale. Results: Group differences were seen in skin and subcutaneous tissue concerns (P=.05), including 3 possible drug rashes and 3 reports of hair color change in the treatment groups. There were 3 adverse event-related discontinuations, including 1 transient bowel obstruction. The plasma Aβ40 concentration was reduced by 58.2% for the 100-mg group and 64.6% for the 140-mg group (P<.001). No significant reduction was seen in cerebrospinal fluid Aβ levels. No group differences were seen in cognitive or functional measures. Conclusions: LY450139 was generally well tolerated at doses of up to 140 mg/d for 14 weeks, with several findings indicating the need for close clinical monitoring in future studies. Decreases in plasma Aβ concentrations were consistent with inhibition of γ-secretase. Trial Registration: clinicaltrials.gov Identifier: NCT00244322
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U2 - 10.1001/archneur.65.8.1031
DO - 10.1001/archneur.65.8.1031
M3 - Article
C2 - 18695053
AN - SCOPUS:49449101906
SN - 0003-9942
VL - 65
SP - 1031
EP - 1038
JO - Archives of Neurology
JF - Archives of Neurology
IS - 8
ER -