Pharmaconutrition Review: Physiological Mechanisms

Robert G. Martindale, Aaron F. Heneghan, Christy M. Lawson, Paul E. Wischmeyer, Rosemary A. Kozar, Kenneth A. Kudsk

Research output: Contribution to journalArticle

31 Scopus citations


The search to improve outcomes in critically ill patients through nutrition support has steadily progressed over the past 4 decades. One current approach to this problem is the addition of specific nutrients as primary therapy to improve host defenses and improve the outcome of critically ill patients. The field is referred to as “pharmaconutrition,” with the hope of focusing investigations on each nutrient to understand its pharmacological effects on immune and clinical outcomes. The purpose of this review is to describe some of the known physiological mechanisms of pharmaconutrients such as glutamine, arginine, ω-3 fatty acids, and selenium.

Original languageEnglish (US)
Pages (from-to)51S-65S
JournalJournal of Parenteral and Enteral Nutrition
StatePublished - Sep 2013



  • immune modulation
  • immunonutrition
  • nutrition therapy
  • pharmaconutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Martindale, R. G., Heneghan, A. F., Lawson, C. M., Wischmeyer, P. E., Kozar, R. A., & Kudsk, K. A. (2013). Pharmaconutrition Review: Physiological Mechanisms. Journal of Parenteral and Enteral Nutrition, 37, 51S-65S.