Pharmacology of dopamine neurons innervating the prefrontal, cingulate and piriform cortices

Michael J. Bannon, Marina Wolf, Robert H. Roth

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The pharmacology of a number of distinct dopamine (DA) systems was studied. Those DA projections possessing autoreceptors (striatum, olfactory tubercle and piriform cortex) exhibited large changes in DA metabolism in response to systemic administration of DA agonists and antagonists. In contrast, in those DA systems which lack autoreceptors (the prefrontal and cingulate cortical innervations) little or no response to DA agonists and a diminished response to DA antagonists was seen. When DA metabolism was inhibited by administration of a MAO inhibitor, reductions in HVA were observed in all brain regions studied. DA turnover appeared faster in the prefrontal and cingulate cortices than in the DA systems possessing autoreceptors.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalEuropean Journal of Pharmacology
Volume92
Issue number1-2
DOIs
StatePublished - Aug 19 1983
Externally publishedYes

Fingerprint

Dopaminergic Neurons
Gyrus Cinguli
Prefrontal Cortex
Dopamine
Pharmacology
Autoreceptors
Dopamine Antagonists
Dopamine Agonists
Monoamine Oxidase Inhibitors
Piriform Cortex
Brain

Keywords

  • Cingulate cortex
  • Dopamine agonists
  • Dopamine antagonists
  • Dopamine turnover
  • Olfactory tubercle
  • Piriform cortex Striatum
  • Prefrontal cortex

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pharmacology of dopamine neurons innervating the prefrontal, cingulate and piriform cortices. / Bannon, Michael J.; Wolf, Marina; Roth, Robert H.

In: European Journal of Pharmacology, Vol. 92, No. 1-2, 19.08.1983, p. 119-125.

Research output: Contribution to journalArticle

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