Pharmacology of dopamine neurons innervating the prefrontal, cingulate and piriform cortices

Michael J. Bannon, Marina Wolf, Robert H. Roth

84 Scopus citations

Abstract

The pharmacology of a number of distinct dopamine (DA) systems was studied. Those DA projections possessing autoreceptors (striatum, olfactory tubercle and piriform cortex) exhibited large changes in DA metabolism in response to systemic administration of DA agonists and antagonists. In contrast, in those DA systems which lack autoreceptors (the prefrontal and cingulate cortical innervations) little or no response to DA agonists and a diminished response to DA antagonists was seen. When DA metabolism was inhibited by administration of a MAO inhibitor, reductions in HVA were observed in all brain regions studied. DA turnover appeared faster in the prefrontal and cingulate cortices than in the DA systems possessing autoreceptors.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalEuropean Journal of Pharmacology
Volume92
Issue number1-2
DOIs
Publication statusPublished - Aug 19 1983
Externally publishedYes

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Keywords

  • Cingulate cortex
  • Dopamine agonists
  • Dopamine antagonists
  • Dopamine turnover
  • Olfactory tubercle
  • Piriform cortex Striatum
  • Prefrontal cortex

ASJC Scopus subject areas

  • Pharmacology

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