Pharmacological studies on stress-induced renin and prolactin secretion: Effects of benzodiazepines, Naloxone, propranolol and diisopropyl fluorophosphate

L. D. Van de Kar, S. A. Lorens, J. H. Urban, K. D. Richardson, J. Paris, C. L. Bethea

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    Stress-induced renin and prolactin secretion was investigated using a conditioned emotional response paradigm. Three minutes after placement in a chamber the rats received an electric shock to their feet via the grid floor, then were immediately returned to their home cage. This procedure was repeated for 3 consecutive days. On the fourth day, instead of receiving an electric shock, they were removed after 3 min and sacrificed by decapitation. Control rats were treated identically with the exception that shock was not administered at any time. There was a significant increase in plasma renin activity and prolactin level in the stressed rats. The administration of the antianxiety drugs chlordiazepoxide (10 mg/kg i.p.) or midazolam (0.125-2 mg/kg i.p.) blocked the stress-induced increase in prolactin levels but not the stress-induced rise in plasma renin activity. Administration of the β-blocker propranolol (1 mg/kg i.p.) inhibited, but did not completely block, stress-induced rise in plasma renin activity and had no effect on stress-induced prolactin secretion. The opiate antagonist naloxone (0.1-10 mg/kg i.p.) and the acetylcholinesterase inhibitor diisopropyl fluorophosphate (0.5 mg/kg i.p.) did not block stress-induced renin of prolactin secretion. It is concluded that stress-induced prolactin secretion is regulated by a benzodiazepine-mediated mechanism and that stress-induced renin but not prolactin secretion is mediated in part via β-receptors.

    Original languageEnglish (US)
    Pages (from-to)257-263
    Number of pages7
    JournalBrain research
    Volume345
    Issue number2
    DOIs
    StatePublished - Oct 21 1985

    Keywords

    • benzodiazepine
    • diisopropyl fluorophosphate (DFP)
    • naloxone
    • prolactin
    • propranolol
    • renin
    • stress induction

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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