Pharmacokinetics, toxicity, and short-term results of cisplatin hyperthermic isolated limb perfusion for soft-tissue sarcoma and melanoma of the extremities

Rodney F. Pommier, H. Stephens Moseley, Jordan Cohen, Chu S. Huang, Rae Ann Townsend, William S. Fletcher

    Research output: Contribution to journalArticle

    46 Scopus citations

    Abstract

    Fifty-nine patients with melanoma or soft tissue sarcoma of the extremities underwent hyperthermic isolated limb perfusion utilizing cisplatin and wide local excision. Doses of cisplatin ranged from 0.75 to 2 mg/kg. The mortality and morbidity rates were 0 and 6.8 percent, respectively. Pharmacokinetic studies indicate that cisplatin is rapidly bound to perfused tissues and remains bound for 1 month. Maximum tumor response in sarcomas occurs 1 to 2 weeks after perfusion, compared with 1 month after perfusions with l-phenylalanine mustard and actinomycin D. Local and regional recurrence rates were 0 and 3.4 percent, respectively, at 1 year. Further studies of hyperthermic limb perfusions with cisplatin are warranted.

    Original languageEnglish (US)
    Pages (from-to)667-671
    Number of pages5
    JournalThe American Journal of Surgery
    Volume155
    Issue number5
    DOIs
    StatePublished - May 1988

    ASJC Scopus subject areas

    • Surgery

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