Pharmacokinetics, toxicity, and short-term results of cisplatin hyperthermic isolated limb perfusion for soft-tissue sarcoma and melanoma of the extremities

Rodney Pommier, H. Stephens Moseley, Jordan Cohen, Chu S. Huang, RaeAnn Townsend, William S. Fletcher

Research output: Contribution to journalArticle

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Abstract

Fifty-nine patients with melanoma or soft tissue sarcoma of the extremities underwent hyperthermic isolated limb perfusion utilizing cisplatin and wide local excision. Doses of cisplatin ranged from 0.75 to 2 mg/kg. The mortality and morbidity rates were 0 and 6.8 percent, respectively. Pharmacokinetic studies indicate that cisplatin is rapidly bound to perfused tissues and remains bound for 1 month. Maximum tumor response in sarcomas occurs 1 to 2 weeks after perfusion, compared with 1 month after perfusions with l-phenylalanine mustard and actinomycin D. Local and regional recurrence rates were 0 and 3.4 percent, respectively, at 1 year. Further studies of hyperthermic limb perfusions with cisplatin are warranted.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalThe American Journal of Surgery
Volume155
Issue number5
DOIs
StatePublished - 1988
Externally publishedYes

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Sarcoma
Cisplatin
Melanoma
Extremities
Pharmacokinetics
Perfusion
Melphalan
Dactinomycin
Morbidity
Recurrence
Mortality
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Pharmacokinetics, toxicity, and short-term results of cisplatin hyperthermic isolated limb perfusion for soft-tissue sarcoma and melanoma of the extremities. / Pommier, Rodney; Moseley, H. Stephens; Cohen, Jordan; Huang, Chu S.; Townsend, RaeAnn; Fletcher, William S.

In: The American Journal of Surgery, Vol. 155, No. 5, 1988, p. 667-671.

Research output: Contribution to journalArticle

Pommier, Rodney ; Moseley, H. Stephens ; Cohen, Jordan ; Huang, Chu S. ; Townsend, RaeAnn ; Fletcher, William S. / Pharmacokinetics, toxicity, and short-term results of cisplatin hyperthermic isolated limb perfusion for soft-tissue sarcoma and melanoma of the extremities. In: The American Journal of Surgery. 1988 ; Vol. 155, No. 5. pp. 667-671.
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