Pharmacokinetics of mivacurium n normal patients and in those with hepatic or renal failure

D. R. Cook, Judith (Judy) Freeman, A. A. Lai, Y. Kang, R. L. Stiller, S. Aggarwal, J. C. Harrelson, R. M. Welch, B. Samara

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

We have determined the pharmacokinetics and duration of action of a bolus dose of mivacurium (0.15 mg kg-1) during isoflurane and nitrous oxide anaesthesia in nine patients with normal renal and liver function, nine patients undergoing cadaveric kidney transplantation and nine patients undergoing cadaveric liver transplantation. Total plasma concentrations of mivacurium were measured for 2.5 h after administration using a high-pressure liquid chromatographic assay. Plasma concentration vs time data for what were presumed to be the two active mivacurium isomers were analysed by a non-compartmental method based on statistical moments. Neuromuscular block was assessed by measuring the electromyographic evoked response of the adductor pollicis muscle to train-of-four stimulation of the ulnar nerve. The mean time to recovery of 25% neuromuscular transmission, T25, was greater in the patients with liver failure (57.2 min) than in control patients (18.7 min). The volume of distribution at steady rate (Vdss) was comparable in the three groups. Patients with impaired liver function had significantly longer mean residence time and smaller plasma clearance than did patients with renal failure or control patients. There were significant negative correlations between plasma cholinesterase activity and both T25 (r = 0.79) and mean residence time (x = 0.62)

Original languageEnglish (US)
Pages (from-to)580-585
Number of pages6
JournalBritish Journal of Anaesthesia
Volume69
Issue number6
DOIs
StatePublished - Dec 1992
Externally publishedYes

Fingerprint

liver failure
Pharmacokinetics
Liver Failure
renal failure
Liver
pharmacokinetics
Renal Insufficiency
Plasma
Plasmas
Transplantation
Residence Time
Neuromuscular Block
Isoflurane
Nitrous Oxide
liver function
Kidney
Clearance
Nerve
Anesthesia
Isomers

Keywords

  • Enzymes: plasma cholinesterase (butyrylcholinesterase)
  • Kidney: renal failure
  • Liver: hepatic failure
  • Neuromuscular relaxants: mivacurium
  • Pharmacokinetics: mivacurium

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Cook, D. R., Freeman, J. J., Lai, A. A., Kang, Y., Stiller, R. L., Aggarwal, S., ... Samara, B. (1992). Pharmacokinetics of mivacurium n normal patients and in those with hepatic or renal failure. British Journal of Anaesthesia, 69(6), 580-585. https://doi.org/10.1093/bja/69.6.580

Pharmacokinetics of mivacurium n normal patients and in those with hepatic or renal failure. / Cook, D. R.; Freeman, Judith (Judy); Lai, A. A.; Kang, Y.; Stiller, R. L.; Aggarwal, S.; Harrelson, J. C.; Welch, R. M.; Samara, B.

In: British Journal of Anaesthesia, Vol. 69, No. 6, 12.1992, p. 580-585.

Research output: Contribution to journalArticle

Cook, DR, Freeman, JJ, Lai, AA, Kang, Y, Stiller, RL, Aggarwal, S, Harrelson, JC, Welch, RM & Samara, B 1992, 'Pharmacokinetics of mivacurium n normal patients and in those with hepatic or renal failure', British Journal of Anaesthesia, vol. 69, no. 6, pp. 580-585. https://doi.org/10.1093/bja/69.6.580
Cook, D. R. ; Freeman, Judith (Judy) ; Lai, A. A. ; Kang, Y. ; Stiller, R. L. ; Aggarwal, S. ; Harrelson, J. C. ; Welch, R. M. ; Samara, B. / Pharmacokinetics of mivacurium n normal patients and in those with hepatic or renal failure. In: British Journal of Anaesthesia. 1992 ; Vol. 69, No. 6. pp. 580-585.
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