Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication

I. M. Kapetanovic, C. D. Torchin, H. J. Kupferberg, D. M. Treiman, C. Di Giorgio, K. Barber, L. Norton, M. Lau, L. Whitley, James Cereghino

Research output: Contribution to journalArticle

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Abstract

This preliminary clinical study describes the pharmacokinetic characteristics of flunarizine (FLN) following single and multiple dosing in epileptic patients receiving comedication. Three groups [phenytoin (PHT) only, carbamazepine (CBZ) only, and PHT plus CBZ] of four patients each were studied. Large interindividual differences, but no statistically significant differences in pharmacokinetic parameters, were observed between the three groups. Following a single dose, mean values (and ranges) for apparent clearance, volume distribution, and elimination half-life (t 1/2 ) were 0.504 L/h/kg (0.086-1.119), 12.431 L (1,959-20,920), and 308 h (61-506), respectively. FLN had no effect on PHT or CBZ steady-state levels but PHT or CBZ appeared to induce the metabolic disposition of FLN. The effect of dose on FLN kinetics could not be evaluated in this preliminary study.

Original languageEnglish (US)
Pages (from-to)770-774
Number of pages5
JournalEpilepsia
Volume29
Issue number6
StatePublished - 1988
Externally publishedYes

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Flunarizine
Carbamazepine
Phenytoin
Pharmacokinetics
Half-Life

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kapetanovic, I. M., Torchin, C. D., Kupferberg, H. J., Treiman, D. M., Di Giorgio, C., Barber, K., ... Cereghino, J. (1988). Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication. Epilepsia, 29(6), 770-774.

Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication. / Kapetanovic, I. M.; Torchin, C. D.; Kupferberg, H. J.; Treiman, D. M.; Di Giorgio, C.; Barber, K.; Norton, L.; Lau, M.; Whitley, L.; Cereghino, James.

In: Epilepsia, Vol. 29, No. 6, 1988, p. 770-774.

Research output: Contribution to journalArticle

Kapetanovic, IM, Torchin, CD, Kupferberg, HJ, Treiman, DM, Di Giorgio, C, Barber, K, Norton, L, Lau, M, Whitley, L & Cereghino, J 1988, 'Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication', Epilepsia, vol. 29, no. 6, pp. 770-774.
Kapetanovic IM, Torchin CD, Kupferberg HJ, Treiman DM, Di Giorgio C, Barber K et al. Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication. Epilepsia. 1988;29(6):770-774.
Kapetanovic, I. M. ; Torchin, C. D. ; Kupferberg, H. J. ; Treiman, D. M. ; Di Giorgio, C. ; Barber, K. ; Norton, L. ; Lau, M. ; Whitley, L. ; Cereghino, James. / Pharmacokinetic profile of flunarizine after single and multiple dosing in epileptic patients receiving comedication. In: Epilepsia. 1988 ; Vol. 29, No. 6. pp. 770-774.
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AU - Torchin, C. D.

AU - Kupferberg, H. J.

AU - Treiman, D. M.

AU - Di Giorgio, C.

AU - Barber, K.

AU - Norton, L.

AU - Lau, M.

AU - Whitley, L.

AU - Cereghino, James

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AB - This preliminary clinical study describes the pharmacokinetic characteristics of flunarizine (FLN) following single and multiple dosing in epileptic patients receiving comedication. Three groups [phenytoin (PHT) only, carbamazepine (CBZ) only, and PHT plus CBZ] of four patients each were studied. Large interindividual differences, but no statistically significant differences in pharmacokinetic parameters, were observed between the three groups. Following a single dose, mean values (and ranges) for apparent clearance, volume distribution, and elimination half-life (t 1/2 ) were 0.504 L/h/kg (0.086-1.119), 12.431 L (1,959-20,920), and 308 h (61-506), respectively. FLN had no effect on PHT or CBZ steady-state levels but PHT or CBZ appeared to induce the metabolic disposition of FLN. The effect of dose on FLN kinetics could not be evaluated in this preliminary study.

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