Pharmacogenetics and personalized medicine: The future for drug prescribing

Zahi Mitri, Maria O. Esmerian, Joseph A. Simaan, Ramzi Sabra, Nathalie Khoueiry Zgheib

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Pharmacogenetics, the study of interindividual variations in DNA sequence related to drug response, aims at the optimization of treatment regimens based on each patient's unique genetic makeup. Currently, there is a trend towards moving away from the concept of "one drug fits all" to a rather more individualized and personalized medicine. The goal is to define the appropriate drug dose that maximizes efficacy and minimizes toxicity in each individual patient. An example of genotyping for CYP2C9 genetic polymorphisms in patients receiving oral anticoagulants is provided. In spite of its inherent challenges, we hope that pharmacogenetic research and clinical applications expand to improve healthcare outcomes in Lebanon and worldwide.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalJournal Medical Libanais
Volume58
Issue number2
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Mitri, Z., Esmerian, M. O., Simaan, J. A., Sabra, R., & Zgheib, N. K. (2010). Pharmacogenetics and personalized medicine: The future for drug prescribing. Journal Medical Libanais, 58(2), 101-104.