Pharmacogenetic tools in the study of drug tolerance and dependence

John Jr Crabbe, John Belknap

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A very brief review of the more common pharmacogenetic methods is presented. At appropriate places, references concerning the more detailed and technical publications available in the literature will be provided. The use of genetically defined populations of animals in research that is aimed at elucidating basic mechanisms underlying drug dependencies will continue to grow. The studies reviewed give a fair sampling of the kinds of information already ascertained using such methods. We hope that it suggests to investigators who do not currently exploit genetic methods that there may be relevant applications for their particular purposes. At the very least, we hope that a clear message is implicit in this review: the utility of the information available with genetically defined strains of animals is only as good as the degree of specification published.

Original languageEnglish (US)
Pages (from-to)385-413
Number of pages29
JournalSubstance and Alcohol Actions/Misuse
Volume1
Issue number5-6
StatePublished - 1980

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Drug Tolerance
Pharmacogenetics
Substance-Related Disorders
tolerance
Animals
drug
animal
Pharmaceutical Preparations
Sampling
available information
Specifications
Publications
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Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pharmacogenetic tools in the study of drug tolerance and dependence. / Crabbe, John Jr; Belknap, John.

In: Substance and Alcohol Actions/Misuse, Vol. 1, No. 5-6, 1980, p. 385-413.

Research output: Contribution to journalArticle

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