Pharmaco-thermodynamics of deuterium-induced oedema in living rat brain via 1H2O MRI: Implications for boron neutron capture therapy of malignant brain tumours

Daniel C. Medina, Xin Li, Charles Jr Springer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In addition to its common usage as a tracer in metabolic and physiological studies, deuterium possesses anti-tumoural activity and confers protection against γ-irradiation. A more recent interest in deuterium emanates from the search for alternatives capable of improving neutron penetrance whilst reducing healthy tissue radiation dose deposition in boron neutron capture therapy of malignant brain tumours. Despite this potential clinical application, deuterium induces brain oedema, which is detrimental to neutron capture therapy. In this study, five adult male rats were titrated with deuterated drinking water while brain oedema was monitored via water proton magnetic resonance imaging. This report concludes that deuterium, as well as deuterium-induced brain oedema, possesses a uniform brain bio-distribution. At a steady-state blood fluid deuteration value of 16%, when the deuterium isotope fraction in drinking water was 25%, a mean oedematous volume change of 9 ± 2% (p-value

Original languageEnglish (US)
Pages (from-to)2127-2139
Number of pages13
JournalPhysics in Medicine and Biology
Volume50
Issue number9
DOIs
StatePublished - May 7 2005

Fingerprint

Boron Neutron Capture Therapy
edema
Deuterium
Thermodynamics
Brain Neoplasms
Magnetic resonance imaging
rats
brain
Boron
Rats
Tumors
deuterium
therapy
Edema
Brain
Neutrons
boron
tumors
neutrons
thermodynamics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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abstract = "In addition to its common usage as a tracer in metabolic and physiological studies, deuterium possesses anti-tumoural activity and confers protection against γ-irradiation. A more recent interest in deuterium emanates from the search for alternatives capable of improving neutron penetrance whilst reducing healthy tissue radiation dose deposition in boron neutron capture therapy of malignant brain tumours. Despite this potential clinical application, deuterium induces brain oedema, which is detrimental to neutron capture therapy. In this study, five adult male rats were titrated with deuterated drinking water while brain oedema was monitored via water proton magnetic resonance imaging. This report concludes that deuterium, as well as deuterium-induced brain oedema, possesses a uniform brain bio-distribution. At a steady-state blood fluid deuteration value of 16{\%}, when the deuterium isotope fraction in drinking water was 25{\%}, a mean oedematous volume change of 9 ± 2{\%} (p-value",
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