Petrosal sinus sampling: Discordant lateralization of ACTH-secreting pituitary microadenomas before and after stimulation with corticotropin-releasing hormone

Donald L. Miller, John L. Doppman, Lynnette K. Nieman, Gordon B. Cutler, George Chrousos, Donald (Lynn) Loriaux, Edward H. Oldfield

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Petrosal sinus sampling was performed 171 times in 157 patients with known or suspected Cushing disease. In all cases, samples for measuring adrenocorticotropic hormone (ACTH) levels were obtained from both inferior petrosal sinuses and a peripheral vein, both before and after intravenous corticotropinreleasing hormone (CRH) administration. In seven examinations in seven patients, a ratio, or gradient, between the ACTH levels in the inferior petrosal sinuses existed in the samples obtained prior to CRH stimulation; however, poststimulation samples demonstrated reversal of the gradient, suggesting lateralization to the contralateral side of the pituitary gland. Data from surgical exploration of the pituitary gland were available for six of these patients, all of whom had adenomas. Prestimulation samples provided correct lateralization in three patients, and in two patients the poststimulation samples provided correct lateralization. One patient had a midline adenoma. When the results of pre- and poststimulation petrosal sinus sampling conflict, neither can be relied on uniformly to provide correct lateralization of ACTH-secreting pituitary adenomas.

Original languageEnglish (US)
Pages (from-to)429-431
Number of pages3
JournalRadiology
Volume176
Issue number2
StatePublished - Aug 1990
Externally publishedYes

Fingerprint

Petrosal Sinus Sampling
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Pituitary Gland
Adenoma
Hormones
Pituitary ACTH Hypersecretion
Pituitary Neoplasms
Veins

Keywords

  • Cushing syndrome, 145.51
  • Hormones
  • Pituitary, neoplasms, 145.371
  • Sinuses, durai, 1775.1299

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Miller, D. L., Doppman, J. L., Nieman, L. K., Cutler, G. B., Chrousos, G., Loriaux, D. L., & Oldfield, E. H. (1990). Petrosal sinus sampling: Discordant lateralization of ACTH-secreting pituitary microadenomas before and after stimulation with corticotropin-releasing hormone. Radiology, 176(2), 429-431.

Petrosal sinus sampling : Discordant lateralization of ACTH-secreting pituitary microadenomas before and after stimulation with corticotropin-releasing hormone. / Miller, Donald L.; Doppman, John L.; Nieman, Lynnette K.; Cutler, Gordon B.; Chrousos, George; Loriaux, Donald (Lynn); Oldfield, Edward H.

In: Radiology, Vol. 176, No. 2, 08.1990, p. 429-431.

Research output: Contribution to journalArticle

Miller, Donald L. ; Doppman, John L. ; Nieman, Lynnette K. ; Cutler, Gordon B. ; Chrousos, George ; Loriaux, Donald (Lynn) ; Oldfield, Edward H. / Petrosal sinus sampling : Discordant lateralization of ACTH-secreting pituitary microadenomas before and after stimulation with corticotropin-releasing hormone. In: Radiology. 1990 ; Vol. 176, No. 2. pp. 429-431.
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