PET measures of pre- and post-synaptic cardiac beta adrenergic function

Jeanne Link, John R. Stratton, Wayne Levy, Jeanne E. Poole, Steven C. Shoner, Werner Stuetzle, James H. Caldwell

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [11C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [11C]-CGP12177 was used to measure cell surface β-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.

Original languageEnglish (US)
Pages (from-to)795-803
Number of pages9
JournalNuclear Medicine and Biology
Volume30
Issue number8
DOIs
Publication statusPublished - Nov 2003
Externally publishedYes

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Keywords

  • [C]- mHED
  • [C]-CGP12177
  • Beta adrenergic
  • Cardiac
  • PET
  • Sympathetic function

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Link, J., Stratton, J. R., Levy, W., Poole, J. E., Shoner, S. C., Stuetzle, W., & Caldwell, J. H. (2003). PET measures of pre- and post-synaptic cardiac beta adrenergic function. Nuclear Medicine and Biology, 30(8), 795-803. https://doi.org/10.1016/j.nucmedbio.2003.09.002