PET measures of pre- and post-synaptic cardiac beta adrenergic function

Jeanne M. Link; John R. Stratton; Wayne Levy; Jeanne E. Poole; Steven C. Shoner; Werner Stuetzle; James H. Caldwell

doi:10.1016/j.nucmedbio.2003.09.002

PET measures of pre- and post-synaptic cardiac beta adrenergic function

Jeanne M. Link, John R. Stratton, Wayne Levy, Jeanne E. Poole, Steven C. Shoner, Werner Stuetzle, James H. Caldwell

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [¹¹C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [¹¹C]-CGP12177 was used to measure cell surface β-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.

Original language	English (US)
Pages (from-to)	795-803
Number of pages	9
Journal	Nuclear Medicine and Biology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.nucmedbio.2003.09.002
State	Published - Nov 2003
Externally published	Yes

Keywords

Beta adrenergic
Cardiac
PET
Sympathetic function
[C]- mHED
[C]-CGP12177

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.nucmedbio.2003.09.002

Cite this

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title = "PET measures of pre- and post-synaptic cardiac beta adrenergic function",

abstract = "Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [11C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [11C]-CGP12177 was used to measure cell surface β-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.",

keywords = "Beta adrenergic, Cardiac, PET, Sympathetic function, [C]- mHED, [C]-CGP12177",

author = "Link, {Jeanne M.} and Stratton, {John R.} and Wayne Levy and Poole, {Jeanne E.} and Shoner, {Steven C.} and Werner Stuetzle and Caldwell, {James H.}",

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AU - Link, Jeanne M.

AU - Stratton, John R.

AU - Levy, Wayne

AU - Poole, Jeanne E.

AU - Shoner, Steven C.

AU - Stuetzle, Werner

AU - Caldwell, James H.

PY - 2003/11

Y1 - 2003/11

N2 - Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [11C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [11C]-CGP12177 was used to measure cell surface β-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.

AB - Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [11C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [11C]-CGP12177 was used to measure cell surface β-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.

KW - Beta adrenergic

KW - Cardiac

KW - PET

KW - Sympathetic function

KW - [C]- mHED

KW - [C]-CGP12177

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PET measures of pre- and post-synaptic cardiac beta adrenergic function

Abstract

Keywords

ASJC Scopus subject areas

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