PET imaging of cellular proliferation

David A. Mankoff, Anthony F. Shields, Kenneth A. Krohn

Research output: Contribution to journalReview article

132 Scopus citations

Abstract

PET cellular proliferation imaging has its roots in a long history of in vitro cellular proliferation studies to characterize cancer and in the understanding of the biology of thymidine incorporation into DNA gained from these studies. PET imaging represents the logical translation of the in vitro work to measure in vivo tumor proliferation. Preclinical studies of [ 11C]-thymidine and other PET-labeled thymidine analogues set the stage for early clinical studies that provided very promising results. Recent progress in the application of [18F]-FLT, a clinically practical PET thymidine analogue, to patient studies sets the next stage for clinical PET cellular proliferation imaging. Further mechanistic studies of the imaging agents and well-designed clinical trials will be important in moving PET proliferation imaging into what is likely to be a significant role in the care of cancer patients by providing a quantitative measure of tumor response to cytotoxic or cytostatic therapy.

Original languageEnglish (US)
Pages (from-to)153-167
Number of pages15
JournalRadiologic Clinics of North America
Volume43
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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