Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II

R. C. Speth, K. L. Grove

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    Rats were tested for dipsogenic and pressor responses to intracerebroventricularly (icv) administered Ang II and for dipsogenic responses to icv administered carbachol in the absence and presence of pertussis toxin, also administered icv. Pertussis toxin did not inhibit the pressor or dipsogenic responses to Ang II, but did inhibit the dipsogenic responses to carbachol. This suggests that the pressor and dipsogenic responses to Ang II in the brain are not mediated by a pertussis toxin-sensitive G protein, but that the muscarinic cholinergic dipsogenic response is mediated by a pertussis toxin-sensitive G protein.

    Original languageEnglish (US)
    Pages (from-to)121-128
    Number of pages8
    JournalRegulatory Peptides
    Volume32
    Issue number2
    DOIs
    StatePublished - Feb 1 1991

    Keywords

    • Angiotensin II receptor
    • Blood pressure
    • Dipsogenesis
    • GTP binding protein
    • Muscarinic cholinergic receptor
    • Pertussis toxin

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Clinical Biochemistry
    • Cellular and Molecular Neuroscience

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