Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II

R. C. Speth, Kevin Grove

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Rats were tested for dipsogenic and pressor responses to intracerebroventricularly (icv) administered Ang II and for dipsogenic responses to icv administered carbachol in the absence and presence of pertussis toxin, also administered icv. Pertussis toxin did not inhibit the pressor or dipsogenic responses to Ang II, but did inhibit the dipsogenic responses to carbachol. This suggests that the pressor and dipsogenic responses to Ang II in the brain are not mediated by a pertussis toxin-sensitive G protein, but that the muscarinic cholinergic dipsogenic response is mediated by a pertussis toxin-sensitive G protein.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalRegulatory Peptides
Volume32
Issue number2
DOIs
StatePublished - Feb 1 1991
Externally publishedYes

Fingerprint

Pertussis Toxin
Carbachol
Angiotensin II
GTP-Binding Proteins
Cholinergic Agents
Rats
Brain

Keywords

  • Angiotensin II receptor
  • Blood pressure
  • Dipsogenesis
  • GTP binding protein
  • Muscarinic cholinergic receptor
  • Pertussis toxin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Pertussis toxin blocks the dipsogenic actions of carbachol, but does not block the dipsogenic and pressor actions of angiotensin II. / Speth, R. C.; Grove, Kevin.

In: Regulatory Peptides, Vol. 32, No. 2, 01.02.1991, p. 121-128.

Research output: Contribution to journalArticle

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