Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee

Jeanne Palmer, Jeannine S. McCune, Miguel Angel Perales, David Marks, Joseph Bubalo, Mohamad Mohty, John R. Wingard, Angelo Paci, Moustapha Hassan, Christopher Bredeson, Joseph Pidala, Nina Shah, Paul Shaughnessy, Navneet Majhail, Jeff Schriber, Bipin N. Savani, Paul A. Carpenter

    Research output: Contribution to journalReview article

    46 Scopus citations

    Abstract

    The Practice Guidelines Committee of the American Society of Blood or Marrow Transplantation (ASBMT) sought to develop an evidence-based review about personalizing busulfan-based conditioning. The Committee sought to grade the relevant published studies (June 1, 2008 through March 31, 2016) according to criteria set forth by the Steering Committee for Evidence Based Reviews from ASBMT. Unfortunately, the published literature was too heterogeneous and lacked adequately powered and sufficiently controlled studies for this to be feasible. Despite this observation, the continued interest in this topic led the Practice Guidelines Committee to develop a list of most frequently asked questions (FAQs) regarding personalized busulfan dosing. This “Considerations” document is a list of these FAQs and their responses, addressing topics of practical relevance to hematopoietic cell transplantation clinicians.

    Original languageEnglish (US)
    Pages (from-to)1915-1925
    Number of pages11
    JournalBiology of Blood and Marrow Transplantation
    Volume22
    Issue number11
    DOIs
    StatePublished - Nov 1 2016

    Keywords

    • Busulfan
    • Hematopoietic cell transplantation
    • Pharmacokinetics
    • Precision medicine
    • Therapeutic drug monitoring

    ASJC Scopus subject areas

    • Hematology
    • Transplantation

    Fingerprint Dive into the research topics of 'Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee'. Together they form a unique fingerprint.

  • Cite this

    Palmer, J., McCune, J. S., Perales, M. A., Marks, D., Bubalo, J., Mohty, M., Wingard, J. R., Paci, A., Hassan, M., Bredeson, C., Pidala, J., Shah, N., Shaughnessy, P., Majhail, N., Schriber, J., Savani, B. N., & Carpenter, P. A. (2016). Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee. Biology of Blood and Marrow Transplantation, 22(11), 1915-1925. https://doi.org/10.1016/j.bbmt.2016.07.013